Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4408175..4408697 Replicon chromosome
Accession NZ_CP091704
Organism Escherichia coli strain KGu016

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag L6L59_RS21115 Protein ID WP_001105433.1
Coordinates 4408175..4408465 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag L6L59_RS21120 Protein ID WP_000212715.1
Coordinates 4408455..4408697 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L59_RS21100 (4403343) 4403343..4404998 + 1656 WP_001550509.1 alpha,alpha-phosphotrehalase -
L6L59_RS21105 (4405392) 4405392..4407530 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
L6L59_RS21110 (4407710) 4407710..4408174 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L6L59_RS21115 (4408175) 4408175..4408465 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L6L59_RS21120 (4408455) 4408455..4408697 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L6L59_RS21125 (4408889) 4408889..4409275 - 387 WP_001232246.1 cytochrome b562 -
L6L59_RS21130 (4409458) 4409458..4410810 - 1353 WP_001162173.1 metalloprotease PmbA -
L6L59_RS21135 (4410904) 4410904..4411455 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
L6L59_RS21140 (4411605) 4411605..4412978 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T234640 WP_001105433.1 NZ_CP091704:c4408465-4408175 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T234640 NZ_LR133964:c3699705-3699388 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT234640 WP_000212715.1 NZ_CP091704:c4408697-4408455 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT234640 NZ_LR133964:c3699395-3699108 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACAGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References