Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2442253..2442779 | Replicon | chromosome |
| Accession | NZ_CP091704 | ||
| Organism | Escherichia coli strain KGu016 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | L6L59_RS11670 | Protein ID | WP_000323025.1 |
| Coordinates | 2442492..2442779 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | L6L59_RS11665 | Protein ID | WP_000534858.1 |
| Coordinates | 2442253..2442492 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L6L59_RS11635 (2437805) | 2437805..2437939 | - | 135 | Protein_2284 | hypothetical protein | - |
| L6L59_RS11640 (2437962) | 2437962..2438701 | + | 740 | Protein_2285 | IS3-like element IS629 family transposase | - |
| L6L59_RS11645 (2439374) | 2439374..2440882 | + | 1509 | WP_001189123.1 | group II intron reverse transcriptase/maturase | - |
| L6L59_RS11650 (2440966) | 2440966..2441445 | + | 480 | Protein_2287 | IS3 family transposase | - |
| L6L59_RS11655 (2441490) | 2441490..2441720 | - | 231 | Protein_2288 | FlxA-like family protein | - |
| L6L59_RS11660 (2441923) | 2441923..2442228 | - | 306 | WP_001326990.1 | protein YdfV | - |
| L6L59_RS11665 (2442253) | 2442253..2442492 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| L6L59_RS11670 (2442492) | 2442492..2442779 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| L6L59_RS11675 (2442851) | 2442851..2443006 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| L6L59_RS11680 (2443223) | 2443223..2443474 | + | 252 | WP_000980994.1 | protein Rem | - |
| L6L59_RS11685 (2443541) | 2443541..2443819 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| L6L59_RS11690 (2443821) | 2443821..2444870 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| L6L59_RS11695 (2444884) | 2444884..2445636 | + | 753 | WP_001047135.1 | antitermination protein | - |
| L6L59_RS11700 (2445914) | 2445914..2446003 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| L6L59_RS11705 (2446058) | 2446058..2446270 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| L6L59_RS11710 (2446571) | 2446571..2446786 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| L6L59_RS11715 (2447150) | 2447150..2447320 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| L6L59_RS11720 (2447540) | 2447540..2447755 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2412527..2480174 | 67647 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T234632 WP_000323025.1 NZ_CP091704:2442492-2442779 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T234632 NZ_LR133932:c1607707-1607489 [Klebsiella oxytoca]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGCTTACGACGTTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCTGATAATGAACTGGCGGTATTTTACTCAGCAGCCGATCATCGTCTTGCTGAAC
TGACGATGAATAAACTGTATGACAAGATCCCGCCATCGGTCTGGAAATTCATCCGCTAA
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGCTTACGACGTTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCTGATAATGAACTGGCGGTATTTTACTCAGCAGCCGATCATCGTCTTGCTGAAC
TGACGATGAATAAACTGTATGACAAGATCCCGCCATCGGTCTGGAAATTCATCCGCTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT234632 WP_000534858.1 NZ_CP091704:2442253-2442492 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT234632 NZ_LR133932:c1608108-1607734 [Klebsiella oxytoca]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTTAATGACCCAACCTCTGCTGTCAATCTTCAGCTTAATGAATTGATCGAGC
ACATTGCCGCGTTCGCACTTAATTATAAAATTAAGTATGCTGAGGATAATAAGCTGGTGACTCAGCTTGACGAATATCTG
GATGACACTTTCGTGTTGTTCAGCAACTACGGCATTAACACTGCAGATCTGCAGAAATGGCGTAAATCAGGCAACAGGTT
ATTCCGCTGCTTTGTGAACGCCAGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAA
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTTAATGACCCAACCTCTGCTGTCAATCTTCAGCTTAATGAATTGATCGAGC
ACATTGCCGCGTTCGCACTTAATTATAAAATTAAGTATGCTGAGGATAATAAGCTGGTGACTCAGCTTGACGAATATCTG
GATGACACTTTCGTGTTGTTCAGCAACTACGGCATTAACACTGCAGATCTGCAGAAATGGCGTAAATCAGGCAACAGGTT
ATTCCGCTGCTTTGTGAACGCCAGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|