Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 825384..826219 Replicon chromosome
Accession NZ_CP091704
Organism Escherichia coli strain KGu016

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2I6T1R7
Locus tag L6L59_RS03935 Protein ID WP_016231184.1
Coordinates 825384..825761 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7Z1I923
Locus tag L6L59_RS03940 Protein ID WP_016231183.1
Coordinates 825851..826219 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L59_RS03905 (820498) 820498..821646 - 1149 WP_000905926.1 capsule polysaccharide export inner-membrane protein KpsE -
L6L59_RS03910 (821718) 821718..822701 - 984 WP_001298261.1 KpsF/GutQ family sugar-phosphate isomerase -
L6L59_RS03915 (823512) 823512..823682 - 171 Protein_768 IS110 family transposase -
L6L59_RS03920 (824024) 824024..824593 - 570 WP_016231187.1 DUF4942 domain-containing protein -
L6L59_RS03925 (824690) 824690..824887 - 198 WP_016231186.1 DUF957 domain-containing protein -
L6L59_RS03930 (824899) 824899..825387 - 489 WP_016231185.1 DUF5983 family protein -
L6L59_RS03935 (825384) 825384..825761 - 378 WP_016231184.1 TA system toxin CbtA family protein Toxin
L6L59_RS03940 (825851) 825851..826219 - 369 WP_016231183.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
L6L59_RS03945 (826269) 826269..826913 - 645 Protein_774 antitoxin of toxin-antitoxin stability system -
L6L59_RS03950 (826932) 826932..827153 - 222 WP_016231182.1 DUF987 domain-containing protein -
L6L59_RS03955 (827216) 827216..827692 - 477 WP_001186774.1 RadC family protein -
L6L59_RS03960 (827708) 827708..828193 - 486 WP_000849596.1 antirestriction protein -
L6L59_RS03965 (828248) 828248..829066 - 819 WP_023909039.1 DUF932 domain-containing protein -
L6L59_RS03970 (829166) 829166..829399 - 234 WP_001119719.1 DUF905 family protein -
L6L59_RS03975 (829485) 829485..829889 + 405 WP_016231180.1 transposase -
L6L59_RS03980 (829886) 829886..830233 + 348 WP_000612617.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14106.07 Da        Isoelectric Point: 8.2905

>T234620 WP_016231184.1 NZ_CP091704:c825761-825384 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T234620 NZ_LR132068:60009-60872 [Enterococcus faecium]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAAAATCGCTTAAATGATAATTTAGAAGAATTGGTTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACGAGTTTGCGATCAGCAATTC
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGCG
AAACTTTATGAGAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTAAG
CGATCAAGGCTATAACTTGGTGATTGAAGGTACAGGACGAACAACAGACGTTCCCATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGGTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGACTTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13613.43 Da        Isoelectric Point: 6.8413

>AT234620 WP_016231183.1 NZ_CP091704:c826219-825851 [Escherichia coli]
MSDTLPGTTLPDNNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ

Download         Length: 369 bp

>AT234620 NZ_LR132068:59735-60007 [Enterococcus faecium]
ATGGCAGTTACTTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAATCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGCTATTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I6T1R7

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z1I923

References