Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3662324..3662919 Replicon chromosome
Accession NZ_CP091703
Organism Escherichia coli strain KOr021

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag L6L60_RS17325 Protein ID WP_019842229.1
Coordinates 3662569..3662919 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag L6L60_RS17320 Protein ID WP_001223213.1
Coordinates 3662324..3662575 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L60_RS17310 (3657989) 3657989..3661768 + 3780 WP_001550503.1 autotransporter assembly complex protein TamB -
L6L60_RS17315 (3661771) 3661771..3662112 + 342 WP_001550504.1 gamma-glutamylcyclotransferase -
L6L60_RS17320 (3662324) 3662324..3662575 + 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
L6L60_RS17325 (3662569) 3662569..3662919 + 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
L6L60_RS17330 (3663123) 3663123..3663653 - 531 WP_000055075.1 inorganic diphosphatase -
L6L60_RS17335 (3663963) 3663963..3664919 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
L6L60_RS17340 (3665051) 3665051..3666553 + 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
L6L60_RS17345 (3666567) 3666567..3667589 + 1023 WP_001550507.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T234611 WP_019842229.1 NZ_CP091703:3662569-3662919 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T234611 NZ_LR130564:c4624195-4624022 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTAGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT234611 WP_001223213.1 NZ_CP091703:3662324-3662575 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT234611 NZ_LR130564:c4624519-4624223 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References