Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1421319..1422024 Replicon chromosome
Accession NZ_CP091703
Organism Escherichia coli strain KOr021

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag L6L60_RS06845 Protein ID WP_000539521.1
Coordinates 1421319..1421705 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag L6L60_RS06850 Protein ID WP_001280945.1
Coordinates 1421695..1422024 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L60_RS06825 (1417323) 1417323..1417949 + 627 WP_001295292.1 glutathione S-transferase GstB -
L6L60_RS06830 (1417946) 1417946..1419061 - 1116 WP_000555051.1 aldose sugar dehydrogenase YliI -
L6L60_RS06835 (1419172) 1419172..1419555 - 384 WP_000497137.1 biofilm formation regulator BssR -
L6L60_RS06840 (1419768) 1419768..1421093 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
L6L60_RS06845 (1421319) 1421319..1421705 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L6L60_RS06850 (1421695) 1421695..1422024 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
L6L60_RS06855 (1422094) 1422094..1423422 - 1329 WP_001550887.1 GGDEF domain-containing protein -
L6L60_RS06860 (1423430) 1423430..1425778 - 2349 WP_001550886.1 EAL domain-containing protein -
L6L60_RS06865 (1425956) 1425956..1426867 - 912 Protein_1354 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T234603 WP_000539521.1 NZ_CP091703:1421319-1421705 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T234603 NZ_LR130564:2796305-2796412 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT234603 WP_001280945.1 NZ_CP091703:1421695-1422024 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT234603 NZ_LR130564:c2796252-2796191 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References