Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142429..142934 Replicon chromosome
Accession NC_011770
Organism Pseudomonas aeruginosa LESB58

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PLES_RS00650 Protein ID WP_003083773.1
Coordinates 142429..142710 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PLES_RS00655 Protein ID WP_003083775.1
Coordinates 142707..142934 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PLES_RS00625 137680..139029 + 1350 WP_012613447.1 C4-dicarboxylate transporter DctA -
PLES_RS00630 139078..139764 + 687 WP_003083762.1 FadR family transcriptional regulator -
PLES_RS00635 139865..140599 + 735 WP_003117208.1 GntR family transcriptional regulator -
PLES_RS00640 140803..141189 + 387 WP_014602345.1 aegerolysin family protein -
PLES_RS00645 141221..142129 - 909 WP_012613448.1 LysR family transcriptional regulator -
PLES_RS00650 142429..142710 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PLES_RS00655 142707..142934 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PLES_RS00660 143110..143730 - 621 WP_003101226.1 hypothetical protein -
PLES_RS00665 143831..144331 + 501 WP_003101228.1 LEA type 2 family protein -
PLES_RS00670 144404..144745 + 342 WP_003101229.1 alkylphosphonate utilization protein -
PLES_RS00675 144827..146254 - 1428 WP_003083784.1 GABA permease -
PLES_RS00680 146423..147916 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T23460 WP_003083773.1 NC_011770:c142710-142429 [Pseudomonas aeruginosa LESB58]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T23460 NC_011770:c142710-142429 [Pseudomonas aeruginosa LESB58]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT23460 WP_003083775.1 NC_011770:c142934-142707 [Pseudomonas aeruginosa LESB58]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT23460 NC_011770:c142934-142707 [Pseudomonas aeruginosa LESB58]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References