Detailed information of TA system TA023459

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2016041..2016669
• Replicon: chromosome
• Accession: NC_011768
• Organism: Desulfatibacillum alkenivorans AK-01

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DALK_RS07905
• Protein ID: WP_012610661.1
• Coordinates: 2016041..2016442 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B8FAD1
• Locus tag: DALK_RS07910
• Protein ID: WP_012610662.1
• Coordinates: 2016442..2016669 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DALK_RS07900	2014428..2015843	-	1416	WP_012610660.1	SpoIIE family protein phosphatase	-
DALK_RS07905	2016041..2016442	-	402	WP_012610661.1	type II toxin-antitoxin system VapC family toxin	Toxin
DALK_RS07910	2016442..2016669	-	228	WP_012610662.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
DALK_RS07915	2017909..2018286	-	378	WP_043807311.1	hypothetical protein	-
DALK_RS07920	2018302..2019324	-	1023	WP_012610663.1	ATP-binding cassette domain-containing protein	-
DALK_RS07925	2019321..2020301	-	981	WP_012610664.1	ABC transporter ATP-binding protein	-
DALK_RS07930	2020313..2021233	-	921	WP_012610665.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (7-50)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14291.64 Da
• Isoelectric Point: 6.9511

>T23459 WP_012610661.1 NC_011768:c2016442-2016041 [Desulfatibacillum aliphaticivorans]
MRYMLDTNICIYLIKRKPAAVVDRLRALSMSDVGISSITLAELEYGVAKSVRPEQNRDALTGFLAPLEIEGFGGQAAACY
GALRAGLEKIGKPIGAMDTLIAAHALSLSAILVTNNTREFERVPGLVVENWAA

Nucleotide

• Length: 402 bp

>T23459 NC_011768:c2016442-2016041 [Desulfatibacillum aliphaticivorans]
ATGCGCTACATGCTCGATACCAATATCTGCATCTACCTCATCAAAAGGAAGCCGGCGGCGGTTGTGGATCGGCTTCGCGC
CTTGTCCATGTCAGATGTTGGGATATCCAGCATCACCCTTGCGGAATTGGAATACGGCGTCGCCAAGAGCGTCCGGCCGG
AGCAAAACCGGGACGCCCTCACCGGCTTTTTGGCCCCTTTGGAAATCGAAGGGTTCGGCGGTCAGGCCGCCGCATGCTAC
GGAGCACTCCGGGCCGGATTGGAAAAAATCGGCAAGCCCATCGGCGCCATGGACACCCTCATTGCCGCTCACGCCCTGTC
TTTGTCTGCAATCCTCGTCACCAACAATACCCGCGAATTCGAACGGGTTCCCGGTTTGGTCGTTGAGAATTGGGCGGCGT
AA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8667.73 Da
• Isoelectric Point: 4.7571

>AT23459 WP_012610662.1 NC_011768:c2016669-2016442 [Desulfatibacillum aliphaticivorans]
MNKAKIFKNGNSQAVRLPKEFQFQGEEVLIKRVGRNVVLSPKDDPWSSLVQSLDLFTEDFMEDRNQPGQDDRESL

Nucleotide

• Length: 228 bp

>AT23459 NC_011768:c2016669-2016442 [Desulfatibacillum aliphaticivorans]
ATGAACAAGGCGAAGATTTTTAAAAACGGAAACAGCCAGGCGGTGAGGCTGCCCAAGGAGTTTCAGTTTCAGGGCGAAGA
AGTGTTGATCAAAAGGGTGGGGCGGAACGTGGTGTTGTCGCCAAAGGATGATCCGTGGAGTTCCCTCGTGCAGAGCCTGG
ACTTGTTCACGGAGGATTTTATGGAGGACCGGAATCAACCCGGTCAGGATGACAGGGAATCCTTGTGA

Structures

Antitoxin

• AlphaFold DB: B8FAD1