Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN-MazE |
Location | 2566811..2567447 | Replicon | chromosome |
Accession | NC_011761 | ||
Organism | Acidithiobacillus ferrooxidans ATCC 23270 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | B7J980 |
Locus tag | AFE_RS13250 | Protein ID | WP_012537455.1 |
Coordinates | 2566811..2567227 (-) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | B7J981 |
Locus tag | AFE_RS13255 | Protein ID | WP_009560865.1 |
Coordinates | 2567214..2567447 (-) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AFE_RS15850 | 2561991..2562143 | - | 153 | WP_009566804.1 | integrase core domain-containing protein | - |
AFE_RS15395 | 2562150..2562437 | - | 288 | WP_012537449.1 | DDE-type integrase/transposase/recombinase | - |
AFE_RS13230 | 2562800..2563726 | - | 927 | WP_012537450.1 | uracil-DNA glycosylase | - |
AFE_RS13235 | 2563893..2564963 | + | 1071 | WP_012537451.1 | linear amide C-N hydrolase | - |
AFE_RS15855 | 2565176..2565550 | - | 375 | WP_196491168.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
AFE_RS13240 | 2565556..2565807 | - | 252 | WP_012537453.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
AFE_RS16255 | 2566127..2566708 | + | 582 | WP_146235847.1 | hypothetical protein | - |
AFE_RS13250 | 2566811..2567227 | - | 417 | WP_012537455.1 | PIN domain-containing protein | Toxin |
AFE_RS13255 | 2567214..2567447 | - | 234 | WP_009560865.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
AFE_RS13260 | 2567446..2567706 | + | 261 | WP_012607558.1 | hypothetical protein | - |
AFE_RS13265 | 2567803..2568153 | + | 351 | WP_012537457.1 | DUF4870 domain-containing protein | - |
AFE_RS13270 | 2568250..2570112 | + | 1863 | WP_012537458.1 | ATP-binding cassette domain-containing protein | - |
AFE_RS13275 | 2570109..2570432 | - | 324 | WP_012537459.1 | hypothetical protein | - |
AFE_RS13280 | 2570425..2570736 | - | 312 | WP_009566855.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15358.75 Da Isoelectric Point: 5.1352
>T23458 WP_012537455.1 NC_011761:c2567227-2566811 [Acidithiobacillus ferrooxidans ATCC 23270]
MASGKAFFDTNVLLYLLSADTAKADVAEGIMVNGGVISAQVLNEFASVAQRKMGMSFLEIREVLTPIHRICDVAHLTLDT
HIHGLRIAERYKYNVWDAMIVASALLADCAVLYTEDMHHGQILEDRLQLINPFLRADE
MASGKAFFDTNVLLYLLSADTAKADVAEGIMVNGGVISAQVLNEFASVAQRKMGMSFLEIREVLTPIHRICDVAHLTLDT
HIHGLRIAERYKYNVWDAMIVASALLADCAVLYTEDMHHGQILEDRLQLINPFLRADE
Download Length: 417 bp
>T23458 NC_011761:c2567227-2566811 [Acidithiobacillus ferrooxidans ATCC 23270]
ATGGCGAGCGGTAAGGCGTTCTTCGACACGAACGTGCTGCTTTATCTGCTTTCGGCGGACACGGCCAAGGCAGATGTTGC
AGAAGGCATCATGGTGAATGGTGGTGTGATCAGTGCCCAGGTGTTGAACGAATTTGCTTCCGTTGCCCAGCGCAAGATGG
GCATGTCTTTTCTGGAAATCAGAGAGGTGCTGACCCCCATTCATCGAATTTGCGATGTCGCGCATCTTACCCTGGATACG
CACATTCATGGCCTCAGGATTGCGGAGCGATACAAATACAATGTTTGGGATGCAATGATTGTCGCATCGGCCCTGTTGGC
TGATTGCGCCGTTCTTTACACGGAGGATATGCACCACGGCCAGATCCTCGAAGACCGCTTGCAACTGATCAATCCATTTT
TGCGGGCCGACGAGTGA
ATGGCGAGCGGTAAGGCGTTCTTCGACACGAACGTGCTGCTTTATCTGCTTTCGGCGGACACGGCCAAGGCAGATGTTGC
AGAAGGCATCATGGTGAATGGTGGTGTGATCAGTGCCCAGGTGTTGAACGAATTTGCTTCCGTTGCCCAGCGCAAGATGG
GCATGTCTTTTCTGGAAATCAGAGAGGTGCTGACCCCCATTCATCGAATTTGCGATGTCGCGCATCTTACCCTGGATACG
CACATTCATGGCCTCAGGATTGCGGAGCGATACAAATACAATGTTTGGGATGCAATGATTGTCGCATCGGCCCTGTTGGC
TGATTGCGCCGTTCTTTACACGGAGGATATGCACCACGGCCAGATCCTCGAAGACCGCTTGCAACTGATCAATCCATTTT
TGCGGGCCGACGAGTGA
Antitoxin
Download Length: 78 a.a. Molecular weight: 8919.15 Da Isoelectric Point: 8.7371
>AT23458 WP_009560865.1 NC_011761:c2567447-2567214 [Acidithiobacillus ferrooxidans ATCC 23270]
MQVSKWGNSLAVRIPTSVVEALGIKEGDDIEVEVVGERRFQIQRTPQAEELLARLRRYRGRLPADFRFDRLEAHGER
MQVSKWGNSLAVRIPTSVVEALGIKEGDDIEVEVVGERRFQIQRTPQAEELLARLRRYRGRLPADFRFDRLEAHGER
Download Length: 234 bp
>AT23458 NC_011761:c2567447-2567214 [Acidithiobacillus ferrooxidans ATCC 23270]
ATGCAGGTATCCAAGTGGGGCAACAGTCTGGCCGTCCGTATACCAACCTCCGTGGTAGAGGCGCTGGGTATCAAAGAGGG
TGACGACATTGAGGTTGAGGTCGTGGGCGAACGCCGTTTTCAGATTCAACGAACGCCTCAAGCGGAAGAGTTGTTGGCCA
GGTTAAGGCGTTATCGAGGGAGGCTCCCTGCCGATTTCAGGTTCGACCGGTTGGAAGCGCATGGCGAGCGGTAA
ATGCAGGTATCCAAGTGGGGCAACAGTCTGGCCGTCCGTATACCAACCTCCGTGGTAGAGGCGCTGGGTATCAAAGAGGG
TGACGACATTGAGGTTGAGGTCGTGGGCGAACGCCGTTTTCAGATTCAACGAACGCCTCAAGCGGAAGAGTTGTTGGCCA
GGTTAAGGCGTTATCGAGGGAGGCTCCCTGCCGATTTCAGGTTCGACCGGTTGGAAGCGCATGGCGAGCGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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