Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2237148..2237786 Replicon chromosome
Accession NZ_CP091700
Organism Escherichia coli strain KFu019

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag L6L55_RS11805 Protein ID WP_000813794.1
Coordinates 2237148..2237324 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L6L55_RS11810 Protein ID WP_001270286.1
Coordinates 2237370..2237786 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L55_RS11785 (2232767) 2232767..2233981 - 1215 WP_096977194.1 BenE family transporter YdcO -
L6L55_RS11790 (2234034) 2234034..2234570 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
L6L55_RS11795 (2234643) 2234643..2236604 + 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
L6L55_RS11800 (2236696) 2236696..2236926 - 231 WP_000494244.1 YncJ family protein -
L6L55_RS11805 (2237148) 2237148..2237324 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
L6L55_RS11810 (2237370) 2237370..2237786 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
L6L55_RS11815 (2237865) 2237865..2239271 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
L6L55_RS11820 (2239516) 2239516..2240661 + 1146 WP_214142448.1 ABC transporter substrate-binding protein -
L6L55_RS11825 (2240679) 2240679..2241692 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
L6L55_RS11830 (2241693) 2241693..2242634 + 942 WP_001251313.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T234576 WP_000813794.1 NZ_CP091700:2237148-2237324 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T234576 NZ_LR130562:c2648296-2648120 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT234576 WP_001270286.1 NZ_CP091700:2237370-2237786 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT234576 NZ_LR130562:c2648074-2647658 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References