234566

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1177301..1177919 Replicon chromosome
Accession NZ_CP091700
Organism Escherichia coli strain KFu019

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag L6L55_RS06495 Protein ID WP_001291435.1
Coordinates 1177301..1177519 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag L6L55_RS06500 Protein ID WP_000344800.1
Coordinates 1177545..1177919 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L55_RS06460 (1172590) 1172590..1173162 + 573 WP_000779831.1 YbaY family lipoprotein -
L6L55_RS06465 (1173193) 1173193..1173504 - 312 WP_000409911.1 MGMT family protein -
L6L55_RS06475 (1173883) 1173883..1174236 + 354 WP_000878140.1 DUF1428 domain-containing protein -
L6L55_RS06480 (1174278) 1174278..1175828 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
L6L55_RS06485 (1175992) 1175992..1176462 - 471 WP_000136192.1 YlaC family protein -
L6L55_RS06490 (1176578) 1176578..1177129 - 552 WP_000102564.1 maltose O-acetyltransferase -
L6L55_RS06495 (1177301) 1177301..1177519 - 219 WP_001291435.1 HHA domain-containing protein Toxin
L6L55_RS06500 (1177545) 1177545..1177919 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
L6L55_RS06505 (1178465) 1178465..1181614 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
L6L55_RS06510 (1181637) 1181637..1182830 - 1194 WP_069907026.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T234566 WP_001291435.1 NZ_CP091700:c1177519-1177301 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T234566 NZ_LR130562:220074-220181 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT234566 WP_000344800.1 NZ_CP091700:c1177919-1177545 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT234566 NZ_LR130562:c220025-219962 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References