Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1404861..1405412 Replicon chromosome
Accession NC_011761
Organism Acidithiobacillus ferrooxidans ATCC 23270

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag AFE_RS07555 Protein ID WP_113527129.1
Coordinates 1404861..1405109 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag AFE_RS07560 Protein ID WP_009566792.1
Coordinates 1405113..1405412 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFE_RS07530 1400330..1401880 + 1551 WP_012607138.1 DUF3363 domain-containing protein -
AFE_RS07540 1402987..1403754 + 768 WP_041647340.1 hypothetical protein -
AFE_RS07545 1404171..1404365 - 195 WP_012607142.1 hypothetical protein -
AFE_RS07550 1404550..1404741 + 192 WP_012607144.1 hypothetical protein -
AFE_RS07555 1404861..1405109 + 249 WP_113527129.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AFE_RS07560 1405113..1405412 + 300 WP_009566792.1 putative addiction module antidote protein Antitoxin
AFE_RS07565 1405521..1405826 + 306 WP_009566791.1 hypothetical protein -
AFE_RS07570 1405978..1406430 + 453 WP_041645837.1 hypothetical protein -
AFE_RS07575 1406427..1407395 + 969 WP_012607146.1 P-type conjugative transfer ATPase TrbB -
AFE_RS07585 1407792..1408583 - 792 WP_009564719.1 hypothetical protein -
AFE_RS07590 1408788..1409174 + 387 WP_012536660.1 TrbC/VirB2 family protein -
AFE_RS07595 1409178..1409555 + 378 WP_012607147.1 VirB3 family type IV secretion system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-79)

Antitoxin

Uncharacterized protein HI1420

(5-94)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9213.68 Da        Isoelectric Point: 9.6876

>T23455 WP_113527129.1 NC_011761:1404861-1405109 [Acidithiobacillus ferrooxidans ATCC 23270]
MRDRRARARVQVRIDRMELAHFGDCEPVGEGVSEMRIHYGPGYRVYLKRFGLELVVLLAGGDKSTQSADIALALKLARQL
EG

Download         Length: 249 bp

>T23455 NC_011761:1404861-1405109 [Acidithiobacillus ferrooxidans ATCC 23270]
CTGCGGGATCGCAGGGCGAGGGCGCGCGTTCAGGTGCGAATCGATCGCATGGAGTTGGCCCATTTTGGCGACTGCGAACC
CGTCGGAGAGGGCGTATCCGAGATGCGTATCCATTACGGTCCCGGCTATCGGGTGTACTTGAAGCGGTTTGGCCTGGAAC
TCGTCGTGCTTCTGGCCGGAGGCGACAAATCCACGCAATCGGCCGACATTGCCCTAGCATTGAAGTTGGCACGACAACTG
GAGGGGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10641.12 Da        Isoelectric Point: 6.0770

>AT23455 WP_009566792.1 NC_011761:1405113-1405412 [Acidithiobacillus ferrooxidans ATCC 23270]
MEKLELHTWDSAEHLKTEADIAAYLDACFEEAGDDAAFIARALGTVARARGMTRLAHDAGMGRESLYKALSGEGNPSFAT
ILKVAKALGVRIRAEALHV

Download         Length: 300 bp

>AT23455 NC_011761:1405113-1405412 [Acidithiobacillus ferrooxidans ATCC 23270]
ATGGAAAAATTGGAATTGCACACATGGGACAGTGCCGAGCACCTGAAAACCGAAGCGGACATCGCGGCTTATCTCGACGC
CTGTTTTGAAGAGGCGGGGGATGACGCGGCCTTCATCGCCAGGGCGCTGGGTACCGTTGCCCGCGCGCGCGGCATGACCC
GGCTGGCCCATGACGCCGGCATGGGCAGGGAAAGCCTCTACAAAGCCCTTTCCGGAGAAGGCAACCCCAGTTTTGCCACC
ATTCTCAAGGTAGCCAAAGCCTTGGGTGTGCGCATTCGCGCCGAAGCTCTGCACGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References