Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1390753..1391790 Replicon chromosome
Accession NC_011761
Organism Acidithiobacillus ferrooxidans ATCC 23270

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag AFE_RS07490 Protein ID WP_009566509.1
Coordinates 1390753..1391325 (-) Length 191 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID B7JAV4
Locus tag AFE_RS07495 Protein ID WP_009566508.1
Coordinates 1391326..1391790 (-) Length 155 a.a.

Genomic Context

AFE_RS07500AFE_RS07470AFE_RS07475AFE_RS16595AFE_RS07490AFE_RS07495AFE_RS15640
Location: 1392226..1396575 (4350 bp)
Type: Others
Protein ID: WP_012607132.1
Location: 1386247..1387242 (996 bp)
Type: Others
Protein ID: WP_012607128.1
Location: 1387850..1389091 (1242 bp)
Type: Others
Protein ID: Protein_1441
Location: 1389601..1390200 (600 bp)
Type: Others
Protein ID: Protein_1442
Location: 1390753..1391325 (573 bp)
Type: Toxin
Protein ID: WP_009566509.1
Location: 1391326..1391790 (465 bp)
Type: Antitoxin
Protein ID: WP_009566508.1
Location: 1391808..1392086 (279 bp)
Type: Others
Protein ID: WP_009566507.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AFE_RS074701386247..1387242-996WP_012607128.1efflux RND transporter periplasmic adaptor subunit-
AFE_RS074751387850..1389091-1242Protein_1441IS3 family transposase-
AFE_RS165951389601..1390200-600Protein_1442transposase-
AFE_RS074901390753..1391325-573WP_009566509.1PIN domain-containing proteinToxin
AFE_RS074951391326..1391790-465WP_009566508.1helix-turn-helix domain-containing proteinAntitoxin
AFE_RS156401391808..1392086-279WP_009566507.1TIR domain-containing protein-
AFE_RS075001392226..1396575+4350WP_012607132.1DUF3560 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1368452..139208623634


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-114)

Antitoxin

Helix-turn-helix domain, group 17

(83-130)


Sequences

Toxin        


Download         Length: 191 a.a.        Molecular weight: 21854.10 Da        Isoelectric Point: 6.2929

>T23454 WP_009566509.1 NC_011761:c1391325-1390753 [Acidithiobacillus ferrooxidans ATCC 23270]
MSSNFIVVYDACVLYPAPLRDLLMRLALTDLYRARWTDMIHDEWTRNVLKQRPDLKAEDLERTRLLMNDHVRDSLVTGFE
HLIPSVELPDADDRHVVAAAIHGGASLIVTFNLKDFPPERLKPYNLTAQHPDDFIFDLLDLHAARVCEAAANHRRSLKYP
PKTVDEYLDTLLKQGLTQTVGQLREWKVAI

Download         Length: 573 bp

>T23454 NC_011761:c1391325-1390753 [Acidithiobacillus ferrooxidans ATCC 23270]
ATGAGTTCGAACTTCATCGTCGTCTACGACGCGTGCGTGCTCTACCCGGCACCGTTGCGCGACCTGCTGATGCGCCTGGC
GCTGACCGATCTGTACCGGGCGCGTTGGACGGACATGATCCACGACGAGTGGACGCGTAACGTTCTGAAGCAGCGGCCAG
ATCTGAAGGCCGAAGACCTGGAGCGAACGCGGTTGTTGATGAATGACCATGTCCGCGACAGCCTGGTCACCGGCTTCGAG
CATCTGATCCCGTCCGTCGAGTTGCCGGACGCCGATGACCGGCATGTGGTGGCTGCCGCTATTCACGGTGGTGCCAGCCT
GATCGTGACGTTCAACCTGAAGGATTTTCCGCCGGAACGGCTCAAACCCTACAACCTGACCGCCCAGCATCCCGACGACT
TCATCTTCGATCTACTGGATCTGCACGCAGCCCGAGTGTGCGAGGCGGCTGCCAACCATCGCCGATCGCTGAAGTACCCA
CCCAAGACAGTTGACGAGTACCTAGACACGCTGCTCAAGCAGGGACTGACACAGACCGTCGGCCAGTTGCGGGAGTGGAA
GGTAGCGATCTGA

Antitoxin


Download         Length: 155 a.a.        Molecular weight: 17042.37 Da        Isoelectric Point: 6.3391

>AT23454 WP_009566508.1 NC_011761:c1391790-1391326 [Acidithiobacillus ferrooxidans ATCC 23270]
MTTRSPTHSLPTAEEVAIARESGRALSAFLQTRAETQQIEIFNDKGASHSVRVPVSALRLLVDVLTEIGEGNAVSIIPIH
AELTTQDAADVLNVSRPFLVQLLERGEIPFHKIGTHRRVRYQDVIAYKERIDAERSKALDALAEQAQALKMGYE

Download         Length: 465 bp

>AT23454 NC_011761:c1391790-1391326 [Acidithiobacillus ferrooxidans ATCC 23270]
ATGACCACACGCTCTCCCACCCATTCGTTGCCGACGGCCGAAGAAGTTGCCATCGCCCGTGAGAGCGGCCGGGCGCTGTC
CGCCTTCCTTCAGACCCGCGCGGAAACCCAGCAGATTGAGATATTCAACGACAAGGGCGCGTCTCATTCGGTCCGCGTCC
CAGTGTCGGCGCTGCGCCTTCTCGTGGACGTACTGACCGAAATCGGTGAGGGCAACGCGGTCAGTATCATCCCGATCCAC
GCCGAACTGACAACACAAGACGCAGCGGACGTACTCAACGTCTCGCGACCGTTCCTCGTCCAGTTGCTGGAGCGCGGTGA
GATCCCATTCCACAAGATCGGAACTCATCGTCGTGTCCGTTACCAGGACGTGATCGCGTACAAGGAGCGGATCGACGCTG
AGCGCAGCAAGGCCCTTGATGCACTGGCCGAGCAAGCCCAGGCGCTCAAGATGGGGTACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBB7JAV4

References