Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2965339..2966171 Replicon chromosome
Accession NZ_CP091691
Organism Escherichia coli strain KMi006

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0Q2Y5N3
Locus tag L6L65_RS14410 Protein ID WP_001514886.1
Coordinates 2965339..2965713 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9IW59
Locus tag L6L65_RS14415 Protein ID WP_001360327.1
Coordinates 2965803..2966171 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L65_RS14385 (2963067) 2963067..2963216 - 150 Protein_2832 hypothetical protein -
L6L65_RS14390 (2963322) 2963322..2963498 - 177 WP_000839290.1 DUF957 domain-containing protein -
L6L65_RS14395 (2963515) 2963515..2963877 - 363 Protein_2834 DUF5983 family protein -
L6L65_RS14400 (2963971) 2963971..2965199 + 1229 WP_155105063.1 IS3 family transposase -
L6L65_RS14405 (2965211) 2965211..2965342 - 132 Protein_2836 DUF5983 family protein -
L6L65_RS14410 (2965339) 2965339..2965713 - 375 WP_001514886.1 TA system toxin CbtA family protein Toxin
L6L65_RS14415 (2965803) 2965803..2966171 - 369 WP_001360327.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
L6L65_RS14420 (2966334) 2966334..2966555 - 222 WP_000692286.1 DUF987 domain-containing protein -
L6L65_RS14425 (2966618) 2966618..2967094 - 477 WP_001186774.1 RadC family protein -
L6L65_RS14430 (2967110) 2967110..2967592 - 483 WP_001508976.1 antirestriction protein -
L6L65_RS14435 (2967684) 2967684..2968502 - 819 WP_089502830.1 DUF932 domain-containing protein -
L6L65_RS14440 (2968620) 2968620..2968815 - 196 Protein_2843 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13930.91 Da        Isoelectric Point: 7.2909

>T234537 WP_001514886.1 NZ_CP091691:c2965713-2965339 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T234537 NZ_LR130555:1003929-1004336 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.34 Da        Isoelectric Point: 5.9598

>AT234537 WP_001360327.1 NZ_CP091691:c2966171-2965803 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT234537 NZ_LR130555:1003682-1003948 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q2Y5N3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9IW59

References