Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2330699..2331317 Replicon chromosome
Accession NZ_CP091691
Organism Escherichia coli strain KMi006

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag L6L65_RS11300 Protein ID WP_001291435.1
Coordinates 2331099..2331317 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag L6L65_RS11295 Protein ID WP_000344800.1
Coordinates 2330699..2331073 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L65_RS11285 (2325788) 2325788..2326981 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L6L65_RS11290 (2327004) 2327004..2330153 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
L6L65_RS11295 (2330699) 2330699..2331073 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
L6L65_RS11300 (2331099) 2331099..2331317 + 219 WP_001291435.1 HHA domain-containing protein Toxin
L6L65_RS11305 (2331489) 2331489..2332040 + 552 WP_000102564.1 maltose O-acetyltransferase -
L6L65_RS11310 (2332156) 2332156..2332626 + 471 WP_000136192.1 YlaC family protein -
L6L65_RS11315 (2332790) 2332790..2334340 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
L6L65_RS11320 (2334382) 2334382..2334735 - 354 WP_000878140.1 DUF1428 domain-containing protein -
L6L65_RS11330 (2335114) 2335114..2335425 + 312 WP_000409911.1 MGMT family protein -
L6L65_RS11335 (2335456) 2335456..2336028 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T234533 WP_001291435.1 NZ_CP091691:2331099-2331317 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T234533 NZ_LR130555:242956-243063 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT234533 WP_000344800.1 NZ_CP091691:2330699-2331073 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT234533 NZ_LR130555:c242907-242844 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References