Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 1371201..1371769 Replicon chromosome
Accession NC_011761
Organism Acidithiobacillus ferrooxidans ATCC 23270

Toxin (Protein)


Gene name vapC Uniprot ID B7JAF4
Locus tag AFE_RS07375 Protein ID WP_009565773.1
Coordinates 1371201..1371575 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AFE_RS15630 Protein ID WP_012607109.1
Coordinates 1371572..1371769 (-) Length 66 a.a.

Genomic Context

AFE_RS07380AFE_RS07385AFE_RS07390AFE_RS07395AFE_RS15635AFE_RS07365AFE_RS07370AFE_RS07375AFE_RS15630AFE_RS16460AFE_RS07400AFE_RS07405AFE_RS07410
Location: 1372599..1373273 (675 bp)
Type: Others
Protein ID: WP_012607112.1
Location: 1373270..1373593 (324 bp)
Type: Others
Protein ID: WP_012607113.1
Location: 1373660..1373935 (276 bp)
Type: Others
Protein ID: WP_012536624.1
Location: 1373947..1374300 (354 bp)
Type: Others
Protein ID: WP_009560827.1
Location: 1374309..1374530 (222 bp)
Type: Others
Protein ID: WP_009560828.1
Location: 1368452..1369651 (1200 bp)
Type: Others
Protein ID: WP_012607107.1
Location: 1369648..1371102 (1455 bp)
Type: Others
Protein ID: WP_012607108.1
Location: 1371201..1371575 (375 bp)
Type: Toxin
Protein ID: WP_009565773.1
Location: 1371572..1371769 (198 bp)
Type: Antitoxin
Protein ID: WP_012607109.1
Location: 1372085..1372246 (162 bp)
Type: Others
Protein ID: WP_012536621.1
Location: 1375133..1375267 (135 bp)
Type: Others
Protein ID: Protein_1426
Location: 1375254..1375523 (270 bp)
Type: Others
Protein ID: WP_012536625.1
Location: 1375548..1376444 (897 bp)
Type: Others
Protein ID: WP_009560830.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AFE_RS073651368452..1369651-1200WP_012607107.1restriction endonuclease subunit S-
AFE_RS073701369648..1371102-1455WP_012607108.1type I restriction-modification system subunit M-
AFE_RS073751371201..1371575-375WP_009565773.1type II toxin-antitoxin system VapC family toxinToxin
AFE_RS156301371572..1371769-198WP_012607109.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
AFE_RS164601372085..1372246-162WP_012536621.1hypothetical protein-
AFE_RS073801372599..1373273+675WP_012607112.1hypothetical protein-
AFE_RS073851373270..1373593+324WP_012607113.1integration host factor subunit alpha-
AFE_RS073901373660..1373935+276WP_012536624.1HU family DNA-binding protein-
AFE_RS073951373947..1374300+354WP_009560827.1hypothetical protein-
AFE_RS156351374309..1374530+222WP_009560828.1HU family DNA-binding protein-
AFE_RS074001375133..1375267-135Protein_1426type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
AFE_RS074051375254..1375523-270WP_012536625.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
AFE_RS074101375548..1376444-897WP_009560830.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1368452..139208623634


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-109)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-46)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13625.67 Da        Isoelectric Point: 6.3157

>T23453 WP_009565773.1 NC_011761:c1371575-1371201 [Acidithiobacillus ferrooxidans ATCC 23270]
MILVDTSVWIDHFRSGDAHLSTLLDHAMVQTHDFIIGEIACGNLKNRQQTLYLLSGLPRCTATSPEETLFFIGRHGLMGR
GIGYIDASILASAMLVQANLWSRDKRLMALATELGCAYSPTSSE

Download         Length: 375 bp

>T23453 NC_011761:c1371575-1371201 [Acidithiobacillus ferrooxidans ATCC 23270]
TTGATTCTGGTCGATACCTCCGTCTGGATCGACCATTTTCGCTCTGGAGATGCACACCTCTCTACTCTGCTTGATCATGC
CATGGTGCAAACGCACGATTTCATCATCGGAGAAATCGCTTGCGGGAATCTCAAAAATCGGCAGCAGACCTTATATCTGC
TCTCAGGCTTACCCCGATGCACCGCCACCTCTCCAGAAGAAACCCTGTTTTTTATTGGGCGTCACGGCCTGATGGGACGC
GGTATAGGCTATATTGACGCGAGTATCCTAGCCTCCGCCATGCTCGTGCAGGCCAATTTATGGTCCCGCGACAAACGTCT
CATGGCTCTGGCTACCGAACTTGGCTGCGCGTACTCGCCGACGTCATCCGAATAG

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7254.32 Da        Isoelectric Point: 9.4896

>AT23453 WP_012607109.1 NC_011761:c1371769-1371572 [Acidithiobacillus ferrooxidans ATCC 23270]
MRTTINLDDELLAQAKTLCGVEDRGALLKEALRALIERESARRLARLGGTEPQLQNTPRRREPAA

Download         Length: 198 bp

>AT23453 NC_011761:c1371769-1371572 [Acidithiobacillus ferrooxidans ATCC 23270]
ATGCGAACGACAATCAACCTGGATGATGAGCTCCTGGCCCAAGCCAAAACGCTCTGTGGCGTAGAAGACCGTGGTGCCCT
CTTAAAAGAGGCCCTGCGTGCTTTGATTGAACGGGAAAGTGCCCGTCGCCTCGCTCGCCTGGGTGGAACAGAACCGCAGT
TACAGAACACTCCTCGCAGACGAGAGCCTGCCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBB7JAF4

Antitoxin

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Source
ID
Structure
No matching records found

References