Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 70011..70536 | Replicon | plasmid pKKo003_2 |
Accession | NZ_CP091685 | ||
Organism | Escherichia coli strain KKo003 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | V0SSI5 |
Locus tag | L6L54_RS25160 | Protein ID | WP_001159868.1 |
Coordinates | 70011..70316 (-) | Length | 102 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | S1PPD8 |
Locus tag | L6L54_RS25165 | Protein ID | WP_000813634.1 |
Coordinates | 70318..70536 (-) | Length | 73 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L6L54_RS25145 (L6L54_25145) | 65921..67087 | - | 1167 | WP_000772446.1 | plasmid-partitioning protein SopA | - |
L6L54_RS25150 (L6L54_25150) | 67675..68430 | - | 756 | WP_000852146.1 | replication initiation protein RepE | - |
L6L54_RS25155 (L6L54_25155) | 69204..70010 | - | 807 | WP_000016982.1 | site-specific integrase | - |
L6L54_RS25160 (L6L54_25160) | 70011..70316 | - | 306 | WP_001159868.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
L6L54_RS25165 (L6L54_25165) | 70318..70536 | - | 219 | WP_000813634.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
L6L54_RS25170 (L6L54_25170) | 71103..71615 | + | 513 | WP_000151784.1 | hypothetical protein | - |
L6L54_RS25175 (L6L54_25175) | 71649..72782 | - | 1134 | WP_001542067.1 | DUF3800 domain-containing protein | - |
L6L54_RS25180 (L6L54_25180) | 72949..73722 | - | 774 | WP_000905949.1 | hypothetical protein | - |
L6L54_RS25185 (L6L54_25185) | 73735..74235 | - | 501 | WP_001773886.1 | HEPN family nuclease | - |
L6L54_RS25190 (L6L54_25190) | 74500..74730 | + | 231 | WP_001261278.1 | type II toxin-antitoxin system VapB family antitoxin | - |
L6L54_RS25195 (L6L54_25195) | 74727..75143 | + | 417 | WP_001034046.1 | type II toxin-antitoxin system VapC family toxin | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / blaTEM-1B | senB | 1..86532 | 86532 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11706.51 Da Isoelectric Point: 6.4674
>T234518 WP_001159868.1 NZ_CP091685:c70316-70011 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T234518 NZ_LR130552:2701225-2701332 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8372.34 Da Isoelectric Point: 4.7405
>AT234518 WP_000813634.1 NZ_CP091685:c70536-70318 [Escherichia coli]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW
Download Length: 219 bp
>AT234518 NZ_LR130552:c2701172-2701111 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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