Detailed information of TA system TA023450

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 1197717..1198342
• Replicon: chromosome
• Accession: NC_011761
• Organism: Acidithiobacillus ferrooxidans ATCC 23270

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: AFE_RS06495
• Protein ID: WP_049759499.1
• Coordinates: 1198034..1198342 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: AFE_RS06490
• Protein ID: WP_041645796.1
• Coordinates: 1197717..1198037 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AFE_RS06460	1192837..1193109	+	273	WP_148208621.1	Y4bD/Y4pK family protein	-
AFE_RS06465	1193241..1193738	+	498	WP_201763906.1	helix-turn-helix domain-containing protein	-
AFE_RS06470	1194000..1196084	+	2085	WP_012607045.1	recombinase family protein	-
AFE_RS15610	1196094..1196840	-	747	Protein_1234	IS21 family transposase	-
AFE_RS16340	1197071..1197208	-	138	WP_158303823.1	hypothetical protein	-
AFE_RS06485	1197505..1197720	-	216	WP_012607049.1	hypothetical protein	-
AFE_RS06490	1197717..1198037	-	321	WP_041645796.1	helix-turn-helix domain-containing protein	Antitoxin
AFE_RS06495	1198034..1198342	-	309	WP_049759499.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AFE_RS06500	1198443..1200025	-	1583	Protein_1239	SAM-dependent DNA methyltransferase	-
AFE_RS16585	1200090..1200248	+	159	WP_201763907.1	hypothetical protein	-
AFE_RS06505	1200631..1201767	+	1137	WP_012536490.1	FIST C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1182262..1205697	23435

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (2-91)

Antitoxin

• HigA2-like, helix-turn-helix domain (10-88)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11664.40 Da
• Isoelectric Point: 9.5079

>T23450 WP_049759499.1 NC_011761:c1198342-1198034 [Acidithiobacillus ferrooxidans ATCC 23270]
MDMPGDVRDTFGYALHLAQIGGKHVQAKPMKGFGSADVVEIVEDSKGDTFRAVYTVRFQERIYVLHCFQKKSTQGIRTPK
PDMDKIHERLKWAERHAKGMTE

Nucleotide

• Length: 309 bp

>T23450 NC_011761:c1198342-1198034 [Acidithiobacillus ferrooxidans ATCC 23270]
ATGGACATGCCTGGGGACGTGCGGGATACCTTTGGGTATGCGCTGCATCTGGCGCAAATTGGCGGCAAGCATGTGCAGGC
CAAGCCGATGAAGGGCTTTGGCTCGGCGGATGTGGTTGAGATTGTCGAGGATTCCAAAGGGGATACATTTCGGGCGGTGT
ACACGGTGCGATTTCAAGAGAGGATCTACGTCCTTCACTGCTTTCAGAAGAAATCTACGCAGGGCATCCGTACACCCAAA
CCGGACATGGACAAGATACACGAGCGGTTGAAATGGGCGGAACGACACGCCAAGGGGATGACTGAATGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11203.11 Da
• Isoelectric Point: 5.0349

>AT23450 WP_041645796.1 NC_011761:c1198037-1197717 [Acidithiobacillus ferrooxidans ATCC 23270]
MNIEMSGGNVYADIGVPDAEEMLLKAQLASRIADMIQGKGLTQSQAAELLGIPQPKLSLMLRGQFRGISEAKMLECLARL
GRDVQIVIGPEHAGTGNIMVVQGGAL

Nucleotide

• Length: 321 bp

>AT23450 NC_011761:c1198037-1197717 [Acidithiobacillus ferrooxidans ATCC 23270]
ATGAACATCGAGATGAGCGGTGGCAATGTCTATGCGGACATCGGTGTGCCCGATGCGGAAGAGATGCTGTTGAAGGCACA
ACTGGCATCCCGGATTGCCGACATGATTCAGGGCAAAGGGCTGACACAATCCCAGGCTGCGGAATTGCTGGGTATCCCGC
AGCCCAAGCTGTCCCTGATGCTACGCGGGCAGTTCCGGGGGATCAGCGAGGCCAAAATGCTGGAATGTCTGGCGCGGCTA
GGGCGAGATGTCCAGATCGTCATTGGTCCGGAACACGCGGGGACCGGAAATATCATGGTGGTACAAGGCGGTGCGCTATG
A