Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbE-relB/ParE-YafN
Location 804909..805434 Replicon chromosome
Accession NC_011761
Organism Acidithiobacillus ferrooxidans ATCC 23270

Toxin (Protein)


Gene name stbE Uniprot ID B7J6U7
Locus tag AFE_RS04175 Protein ID WP_009564272.1
Coordinates 805153..805434 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B7J6U6
Locus tag AFE_RS04170 Protein ID WP_009564270.1
Coordinates 804909..805163 (+) Length 85 a.a.

Genomic Context

AFE_RS04135AFE_RS04140AFE_RS04145AFE_RS04150AFE_RS04155AFE_RS15220AFE_RS04165AFE_RS04170AFE_RS04175AFE_RS04190AFE_RS04130AFE_RS04185
Location: 800825..801269 (445 bp)
Type: Others
Protein ID: Protein_817
Location: 801438..802106 (669 bp)
Type: Others
Protein ID: WP_009561118.1
Location: 802103..803266 (1164 bp)
Type: Others
Protein ID: WP_012536412.1
Location: 803263..803352 (90 bp)
Type: Others
Protein ID: Protein_820
Location: 803324..803609 (286 bp)
Type: Others
Protein ID: Protein_821
Location: 803840..804175 (336 bp)
Type: Others
Protein ID: WP_012536413.1
Location: 804362..804661 (300 bp)
Type: Others
Protein ID: WP_009564269.1
Location: 804909..805163 (255 bp)
Type: Antitoxin
Protein ID: WP_009564270.1
Location: 805153..805434 (282 bp)
Type: Toxin
Protein ID: WP_009564272.1
Location: 807355..808407 (1053 bp)
Type: Others
Protein ID: WP_012536417.1
Location: 799956..800627 (672 bp)
Type: Others
Protein ID: WP_012536411.1
Location: 805977..807200 (1224 bp)
Type: Others
Protein ID: WP_012606680.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AFE_RS04130799956..800627-672WP_012536411.1LysR family transcriptional regulator-
AFE_RS04135800825..801269+445Protein_817SDR family oxidoreductase-
AFE_RS04140801438..802106+669WP_009561118.1cupin domain-containing protein-
AFE_RS04145802103..803266+1164WP_012536412.1FAD-dependent oxidoreductase-
AFE_RS04150803263..803352+90Protein_820short-chain dehydrogenase-
AFE_RS04155803324..803609+286Protein_821hypothetical protein-
AFE_RS15220803840..804175+336WP_012536413.1shufflon-specific DNA recombinase-
AFE_RS04165804362..804661+300WP_009564269.1YbjQ family protein-
AFE_RS04170804909..805163+255WP_009564270.1antitoxinAntitoxin
AFE_RS04175805153..805434+282WP_009564272.1type II toxin-antitoxin system RelE/ParE family toxinToxin
AFE_RS04185805977..807200-1224WP_012606680.1class I SAM-dependent rRNA methyltransferase-
AFE_RS04190807355..808407+1053WP_012536417.1S-methyl-5-thioribose-1-phosphate isomerase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10757.61 Da        Isoelectric Point: 10.6855

>T23448 WP_009564272.1 NC_011761:805153-805434 [Acidithiobacillus ferrooxidans ATCC 23270]
MPYELTFHPSALKEWQALDHSVRAPFKKKLAERLVHPRVPSAQLHGHPDRYKIKLRSIGYRLIYQVMETEVQVLVLAVGK
REGSVAYHKAKGR

Download         Length: 282 bp

>T23448 NC_011761:805153-805434 [Acidithiobacillus ferrooxidans ATCC 23270]
ATGCCTTATGAGCTCACTTTCCATCCCTCCGCCCTCAAAGAATGGCAGGCCTTGGACCATAGCGTCCGTGCCCCATTCAA
AAAGAAACTGGCAGAACGCTTAGTGCACCCACGCGTCCCTTCCGCTCAACTGCATGGCCACCCGGATCGCTATAAGATCA
AACTCCGCAGCATAGGCTATCGCTTGATCTACCAAGTGATGGAAACGGAAGTCCAAGTGTTGGTCCTGGCGGTAGGCAAG
CGGGAAGGCTCTGTCGCCTATCACAAGGCCAAAGGACGCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8832.16 Da        Isoelectric Point: 4.6615

>AT23448 WP_009564270.1 NC_011761:804909-805163 [Acidithiobacillus ferrooxidans ATCC 23270]
MTHVILADVAASVSELKKNPMGTVAAGEGATVAILNRNEPAFYCVPAATYAALLEHLENLELNALAESRLKDGQTPIKVS
LDAL

Download         Length: 255 bp

>AT23448 NC_011761:804909-805163 [Acidithiobacillus ferrooxidans ATCC 23270]
ATGACCCACGTCATTCTTGCCGATGTTGCTGCCAGTGTTTCCGAACTCAAAAAGAACCCTATGGGAACCGTGGCCGCAGG
AGAAGGGGCTACTGTGGCCATTCTCAACCGCAACGAACCGGCTTTTTACTGTGTCCCAGCCGCTACCTATGCTGCGCTTC
TGGAACATCTGGAAAATTTGGAGCTGAACGCTTTGGCGGAAAGCCGTCTGAAGGATGGCCAAACCCCGATCAAGGTGTCG
CTGGATGCCTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBB7J6U7

Antitoxin

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Source
ID
Structure
AlphaFold DBB7J6U6

References