Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 418549..419189 Replicon chromosome
Accession NC_011761
Organism Acidithiobacillus ferrooxidans ATCC 23270

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AFE_RS02260 Protein ID WP_009567232.1
Coordinates 418779..419189 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID B7J4M0
Locus tag AFE_RS02255 Protein ID WP_009567231.1
Coordinates 418549..418779 (+) Length 77 a.a.

Genomic Context

AFE_RS02240AFE_RS02245AFE_RS02250AFE_RS02255AFE_RS02260AFE_RS02265AFE_RS02270AFE_RS02275AFE_RS02280
Location: 414427..415557 (1131 bp)
Type: Others
Protein ID: WP_012536159.1
Location: 415557..416522 (966 bp)
Type: Others
Protein ID: WP_009567244.1
Location: 416523..418340 (1818 bp)
Type: Others
Protein ID: WP_012536160.1
Location: 418549..418779 (231 bp)
Type: Antitoxin
Protein ID: WP_009567231.1
Location: 418779..419189 (411 bp)
Type: Toxin
Protein ID: WP_009567232.1
Location: 419322..420420 (1099 bp)
Type: Others
Protein ID: WP_012606567.1
Location: 420457..421947 (1491 bp)
Type: Others
Protein ID: WP_009568984.1
Location: 421944..423188 (1245 bp)
Type: Others
Protein ID: WP_012536161.1
Location: 423181..423876 (696 bp)
Type: Others
Protein ID: WP_009566877.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AFE_RS02240414427..415557+1131WP_012536159.1threonine synthase-
AFE_RS02245415557..416522+966WP_009567244.1hypothetical protein-
AFE_RS02250416523..418340+1818WP_012536160.1single-stranded DNA exonuclease-
AFE_RS02255418549..418779+231WP_009567231.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
AFE_RS02260418779..419189+411WP_009567232.1type II toxin-antitoxin system VapC family toxinToxin
AFE_RS02265419322..420420+1099WP_012606567.1peptide chain release factor 2-
AFE_RS02270420457..421947+1491WP_009568984.1lysine--tRNA ligase-
AFE_RS02275421944..423188+1245WP_012536161.1lipoprotein-releasing ABC transporter permease subunit-
AFE_RS02280423181..423876+696WP_009566877.1ABC transporter ATP-binding protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-127)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15278.46 Da        Isoelectric Point: 7.3848

>T23447 WP_009567232.1 NC_011761:418779-419189 [Acidithiobacillus ferrooxidans ATCC 23270]
MTLRYLLDTNICIYIAKHHPPAVRERFVQHGADDLAMSVITLGELCWGAEKSQARDKALASIQRLQERIQVAPLTPQVGI
HYGQIRAALESGGRPIGNNDLWIAAHARAEGWIVVTNNEREFRRVEGLQVENWVTA

Download         Length: 411 bp

>T23447 NC_011761:418779-419189 [Acidithiobacillus ferrooxidans ATCC 23270]
ATGACCTTGCGTTATCTGCTGGATACCAATATCTGCATTTATATTGCCAAACACCATCCGCCCGCCGTGCGGGAGCGTTT
TGTACAACATGGTGCCGATGATCTGGCGATGTCGGTAATCACCTTGGGTGAATTGTGTTGGGGTGCGGAAAAAAGTCAGG
CGCGTGACAAAGCGTTGGCCAGCATACAGCGCCTGCAAGAACGTATTCAGGTGGCCCCCCTCACCCCTCAGGTCGGCATC
CACTATGGCCAGATCCGCGCGGCTCTGGAAAGCGGCGGGCGGCCCATTGGCAATAATGATCTGTGGATCGCCGCACACGC
CCGCGCCGAAGGCTGGATCGTAGTTACCAACAATGAACGAGAGTTCCGACGGGTGGAAGGATTGCAAGTGGAAAACTGGG
TAACGGCATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.76 Da        Isoelectric Point: 4.4217

>AT23447 WP_009567231.1 NC_011761:418549-418779 [Acidithiobacillus ferrooxidans ATCC 23270]
MAIARIFQSGNSQAVRLPKEFRFEVDQVEIFRRGNEIILREHPVDGTGVFDALADLPEDFMSDGRQDIPPQARENF

Download         Length: 231 bp

>AT23447 NC_011761:418549-418779 [Acidithiobacillus ferrooxidans ATCC 23270]
ATGGCCATCGCACGCATCTTCCAATCAGGCAACAGTCAGGCCGTACGGTTGCCCAAAGAATTCCGCTTTGAGGTGGATCA
GGTGGAAATCTTCCGCCGCGGGAATGAGATTATTCTGCGGGAGCATCCAGTGGATGGTACAGGCGTTTTTGATGCCCTGG
CCGACCTTCCCGAAGACTTCATGTCCGACGGACGCCAGGATATTCCACCCCAGGCAAGGGAAAACTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
No matching records found

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBB7J4M0

References