Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2041942..2042580 Replicon chromosome
Accession NZ_CP091677
Organism Escherichia coli strain KFu022

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag L6L66_RS10100 Protein ID WP_000813794.1
Coordinates 2041942..2042118 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L6L66_RS10105 Protein ID WP_001270286.1
Coordinates 2042164..2042580 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L66_RS10080 (2037561) 2037561..2038736 - 1176 WP_001236265.1 BenE family transporter YdcO -
L6L66_RS10085 (2038828) 2038828..2039364 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
L6L66_RS10090 (2039437) 2039437..2041398 + 1962 WP_032238462.1 23S rRNA 5-hydroxycytidine C2501 synthase -
L6L66_RS10095 (2041490) 2041490..2041720 - 231 WP_000494244.1 YncJ family protein -
L6L66_RS10100 (2041942) 2041942..2042118 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
L6L66_RS10105 (2042164) 2042164..2042580 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
L6L66_RS10110 (2042659) 2042659..2044065 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
L6L66_RS10115 (2044310) 2044310..2045455 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
L6L66_RS10120 (2045473) 2045473..2046486 + 1014 WP_000220399.1 ABC transporter ATP-binding protein -
L6L66_RS10125 (2046487) 2046487..2047428 + 942 WP_001251313.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T234466 WP_000813794.1 NZ_CP091677:2041942-2042118 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T234466 NZ_LR130545:258122-258229 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT234466 WP_001270286.1 NZ_CP091677:2042164-2042580 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT234466 NZ_LR130545:c258065-258008 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References