Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
| Location | 4288297..4288892 | Replicon | chromosome |
| Accession | NZ_CP091673 | ||
| Organism | Escherichia coli strain KKo009 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | D6JG31 |
| Locus tag | L6L68_RS21890 | Protein ID | WP_000155159.1 |
| Coordinates | 4288297..4288674 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | D6JG32 |
| Locus tag | L6L68_RS21895 | Protein ID | WP_000557315.1 |
| Coordinates | 4288671..4288892 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L6L68_RS21870 (4283795) | 4283795..4284865 | - | 1071 | WP_000907828.1 | sn-glycerol 3-phosphate ABC transporter ATP binding protein UgpC | - |
| L6L68_RS21875 (4284867) | 4284867..4285712 | - | 846 | WP_000572164.1 | sn-glycerol-3-phosphate ABC transporter permease UgpE | - |
| L6L68_RS21880 (4285709) | 4285709..4286596 | - | 888 | WP_000099289.1 | sn-glycerol-3-phosphate ABC transporter permease UgpA | - |
| L6L68_RS21885 (4286772) | 4286772..4288088 | - | 1317 | WP_000803191.1 | sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB | - |
| L6L68_RS21890 (4288297) | 4288297..4288674 | - | 378 | WP_000155159.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| L6L68_RS21895 (4288671) | 4288671..4288892 | - | 222 | WP_000557315.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| L6L68_RS21900 (4288980) | 4288980..4289693 | - | 714 | WP_000416895.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF | - |
| L6L68_RS21905 (4289695) | 4289695..4290462 | - | 768 | WP_000082101.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG | - |
| L6L68_RS21910 (4290459) | 4290459..4291736 | - | 1278 | WP_000803825.1 | branched chain amino acid ABC transporter permease LivM | - |
| L6L68_RS21915 (4291733) | 4291733..4292659 | - | 927 | WP_000003010.1 | high-affinity branched-chain amino acid ABC transporter permease LivH | - |
| L6L68_RS21920 (4292707) | 4292707..4293816 | - | 1110 | WP_001318085.1 | high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4283055..4299004 | 15949 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13964.25 Da Isoelectric Point: 6.7263
>T234444 WP_000155159.1 NZ_CP091673:c4288674-4288297 [Escherichia coli]
MTIQFISAEEIIYFHDKLLSVTPGVTGMSDPGRAEALLYRVLNKYEYEGVSDLWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILAANPEFVELTVDVAAGKVSLEDIVTRLRQRGT
MTIQFISAEEIIYFHDKLLSVTPGVTGMSDPGRAEALLYRVLNKYEYEGVSDLWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILAANPEFVELTVDVAAGKVSLEDIVTRLRQRGT
Download Length: 378 bp
>T234444 NZ_LR130543:341658-342005 [Klebsiella variicola]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGGTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGACGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGGTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGACGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8103.24 Da Isoelectric Point: 6.2168
>AT234444 WP_000557315.1 NZ_CP091673:c4288892-4288671 [Escherichia coli]
MHTMNYSEARQNLALVLETAATGTPVTITRRGHKAAVIISAEEFERYQKAKLDAEFDAIMAIHGSEIKELADK
MHTMNYSEARQNLALVLETAATGTPVTITRRGHKAAVIISAEEFERYQKAKLDAEFDAIMAIHGSEIKELADK
Download Length: 222 bp
>AT234444 NZ_LR130543:342005-342304 [Klebsiella variicola]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGATCCGCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACGTTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGATCCGCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACGTTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|