Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3806726..3807524 Replicon chromosome
Accession NZ_CP091673
Organism Escherichia coli strain KKo009

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag L6L68_RS19455 Protein ID WP_000854735.1
Coordinates 3807147..3807524 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag L6L68_RS19450 Protein ID WP_032153712.1
Coordinates 3806726..3807100 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L68_RS19415 (3802459) 3802459..3803343 + 885 WP_024166630.1 50S ribosome-binding GTPase -
L6L68_RS19420 (3803462) 3803462..3804139 + 678 WP_240729675.1 hypothetical protein -
L6L68_RS19425 (3804169) 3804169..3804378 + 210 WP_023155727.1 DUF905 family protein -
L6L68_RS19430 (3804469) 3804469..3805287 + 819 WP_001234693.1 DUF932 domain-containing protein -
L6L68_RS19435 (3805379) 3805379..3805864 + 486 WP_032153711.1 antirestriction protein -
L6L68_RS19440 (3805880) 3805880..3806356 + 477 WP_001186715.1 RadC family protein -
L6L68_RS19445 (3806425) 3806425..3806646 + 222 WP_000692345.1 DUF987 domain-containing protein -
L6L68_RS19450 (3806726) 3806726..3807100 + 375 WP_032153712.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
L6L68_RS19455 (3807147) 3807147..3807524 + 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
L6L68_RS19460 (3807521) 3807521..3808012 + 492 WP_023155722.1 DUF5983 family protein -
L6L68_RS19465 (3808024) 3808024..3808221 + 198 WP_000839265.1 DUF957 domain-containing protein -
L6L68_RS19470 (3808306) 3808306..3809172 + 867 WP_032153714.1 DUF4942 domain-containing protein -
L6L68_RS19475 (3809244) 3809244..3809507 + 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
L6L68_RS19480 (3809504) 3809504..3809830 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
L6L68_RS19485 (3810245) 3810245..3810781 - 537 WP_000942790.1 GspM family type II secretion system protein YghD -
L6L68_RS19490 (3810783) 3810783..3811961 - 1179 WP_021557196.1 type II secretion system protein GspL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3750380..3809830 59450


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T234442 WP_000854735.1 NZ_CP091673:3807147-3807524 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T234442 NZ_LR130543:274956-275231 [Klebsiella variicola]
ATGGAGCAGCAGGTTTTATCTTTACGTAATAAACAGCACCACACGCTGGAGCAACTGTTTAAAATCCCTGTGCCACAGGG
CATTAAATGGGCCGACATTGAATCGCTAATTAAAGCGTTAGGCGGGGAGATTAAAGAAGGACGCGGCTCGCGCTGTAAAT
TTTTGTTGAACCACAGCATTGCCAGCTTTCACAGGCCTCATCCTTCGCCGGATACTGACAAAGGCGCCGTGGAGAGCGTG
CGCGATTGGTTAATCACTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT234442 WP_032153712.1 NZ_CP091673:3806726-3807100 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT234442 NZ_LR130543:275228-275587 [Klebsiella variicola]
ATGATCAAACCTAAAACGCCAAACTCAATGGAGATTGCCGGCCAGCCTGCCGTTATCAATTACGTGCCTGAGCTCAATGC
ATTCCGCGGTAAGTTCCTTGGATTATCAGGATATTGCGATTTTGTTTCCGATAGTATTCAAGGGTTACAACAGGAGGGCG
AGATATCATTACAGGAGTATCTCGCAGATTGTCATGAAGCGGGGATTGAGCCTTATGCTCACCCGGAAAAGATGAAAACC
TTCACGCTGCGCTATCCTGAGTCATTTGGCGAGCGTCTTAGCTCCGCCGCTGCGGAGGAGCAGGTTTCCGTAAATACCTG
GATCCTTGAGACGCTCAATGAACGTCTCAAACAGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References