Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 2744022..2744670 | Replicon | chromosome |
Accession | NC_011757 | ||
Organism | Methylobacterium extorquens CM4 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | B7L2G2 |
Locus tag | MCHL_RS12640 | Protein ID | WP_015950975.1 |
Coordinates | 2744022..2744225 (+) | Length | 68 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | B7L2G3 |
Locus tag | MCHL_RS12645 | Protein ID | WP_015950976.1 |
Coordinates | 2744263..2744670 (+) | Length | 136 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MCHL_RS12620 | 2739499..2740014 | + | 516 | WP_015950972.1 | signal peptidase II | - |
MCHL_RS12625 | 2740177..2740881 | + | 705 | WP_015950973.1 | hypothetical protein | - |
MCHL_RS12630 | 2741074..2742456 | + | 1383 | WP_003599161.1 | insulinase family protein | - |
MCHL_RS12635 | 2742528..2743811 | + | 1284 | WP_015950974.1 | insulinase family protein | - |
MCHL_RS12640 | 2744022..2744225 | + | 204 | WP_015950975.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
MCHL_RS12645 | 2744263..2744670 | + | 408 | WP_015950976.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
MCHL_RS12650 | 2744753..2745685 | + | 933 | WP_015950977.1 | ring-cleaving dioxygenase | - |
MCHL_RS12655 | 2745855..2746628 | + | 774 | WP_003599169.1 | ferredoxin--NADP reductase | - |
MCHL_RS12660 | 2746923..2747600 | + | 678 | WP_015950978.1 | dethiobiotin synthase | - |
MCHL_RS12665 | 2747607..2747966 | - | 360 | WP_003599173.1 | hypothetical protein | - |
MCHL_RS12670 | 2748001..2748420 | - | 420 | WP_003599175.1 | response regulator | - |
MCHL_RS12675 | 2748688..2749362 | + | 675 | WP_015822797.1 | DUF1275 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 68 a.a. Molecular weight: 7724.78 Da Isoelectric Point: 11.7277
>T23444 WP_015950975.1 NC_011757:2744022-2744225 [Methylorubrum extorquens CM4]
VSNRAKETRSLIVRLRDDGWIVARKGPGDHVQYKHPTKPGRVTLDTGRREQALGTLRSIFRQAGWEW
VSNRAKETRSLIVRLRDDGWIVARKGPGDHVQYKHPTKPGRVTLDTGRREQALGTLRSIFRQAGWEW
Download Length: 204 bp
>T23444 NC_011757:2744022-2744225 [Methylorubrum extorquens CM4]
GTGTCGAATCGCGCCAAGGAAACGCGCAGCCTCATAGTCCGACTGCGCGATGATGGTTGGATCGTTGCCCGGAAGGGGCC
GGGCGACCATGTCCAGTACAAACATCCAACGAAACCGGGACGTGTGACGCTGGATACCGGGCGCCGCGAGCAGGCGCTGG
GTACGCTCCGCAGCATCTTCAGGCAGGCGGGGTGGGAATGGTGA
GTGTCGAATCGCGCCAAGGAAACGCGCAGCCTCATAGTCCGACTGCGCGATGATGGTTGGATCGTTGCCCGGAAGGGGCC
GGGCGACCATGTCCAGTACAAACATCCAACGAAACCGGGACGTGTGACGCTGGATACCGGGCGCCGCGAGCAGGCGCTGG
GTACGCTCCGCAGCATCTTCAGGCAGGCGGGGTGGGAATGGTGA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14531.49 Da Isoelectric Point: 4.4886
>AT23444 WP_015950976.1 NC_011757:2744263-2744670 [Methylorubrum extorquens CM4]
MTRVVMLIHGEAGNYGASFPDFPGATTGADDLDELYRKAAEMLAFHVGGLVEDGELVPRTRSLEELRGDPVFIEESRDAM
IGLIEVDLPGRAVRVNISVEESLLKRIDRAAEAAGESRSGFLAQAAKARLTSMVA
MTRVVMLIHGEAGNYGASFPDFPGATTGADDLDELYRKAAEMLAFHVGGLVEDGELVPRTRSLEELRGDPVFIEESRDAM
IGLIEVDLPGRAVRVNISVEESLLKRIDRAAEAAGESRSGFLAQAAKARLTSMVA
Download Length: 408 bp
>AT23444 NC_011757:2744263-2744670 [Methylorubrum extorquens CM4]
ATGACGCGGGTCGTCATGCTGATTCACGGCGAAGCCGGCAATTACGGCGCGTCTTTCCCGGATTTTCCCGGTGCGACGAC
GGGCGCCGACGATCTCGACGAGCTCTACCGGAAGGCCGCCGAGATGCTGGCCTTCCATGTCGGCGGCTTGGTGGAGGATG
GCGAACTGGTGCCGCGGACCCGCTCGCTTGAAGAACTGCGCGGCGACCCCGTTTTCATTGAGGAAAGCCGGGACGCGATG
ATCGGCCTGATCGAGGTCGATCTCCCGGGGCGTGCCGTGCGGGTGAACATCTCGGTCGAGGAGAGTCTGCTCAAGCGGAT
CGACCGCGCGGCCGAGGCCGCCGGCGAGAGCCGATCCGGCTTCCTCGCGCAGGCCGCGAAGGCGCGCCTGACGTCCATGG
TGGCCTGA
ATGACGCGGGTCGTCATGCTGATTCACGGCGAAGCCGGCAATTACGGCGCGTCTTTCCCGGATTTTCCCGGTGCGACGAC
GGGCGCCGACGATCTCGACGAGCTCTACCGGAAGGCCGCCGAGATGCTGGCCTTCCATGTCGGCGGCTTGGTGGAGGATG
GCGAACTGGTGCCGCGGACCCGCTCGCTTGAAGAACTGCGCGGCGACCCCGTTTTCATTGAGGAAAGCCGGGACGCGATG
ATCGGCCTGATCGAGGTCGATCTCCCGGGGCGTGCCGTGCGGGTGAACATCTCGGTCGAGGAGAGTCTGCTCAAGCGGAT
CGACCGCGCGGCCGAGGCCGCCGGCGAGAGCCGATCCGGCTTCCTCGCGCAGGCCGCGAAGGCGCGCCTGACGTCCATGG
TGGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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