Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4672977..4673775 Replicon chromosome
Accession NZ_CP091665
Organism Escherichia coli strain KOr019

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag L6L58_RS22425 Protein ID WP_000854735.1
Coordinates 4673398..4673775 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag L6L58_RS22420 Protein ID WP_001285415.1
Coordinates 4672977..4673351 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L58_RS22385 (4668717) 4668717..4669601 + 885 WP_023563932.1 50S ribosome-binding GTPase -
L6L58_RS22390 (4669720) 4669720..4670397 + 678 WP_001097368.1 hypothetical protein -
L6L58_RS22395 (4670403) 4670403..4670636 + 234 WP_032288847.1 DUF905 family protein -
L6L58_RS22400 (4670726) 4670726..4671544 + 819 WP_024214765.1 DUF932 domain-containing protein -
L6L58_RS22405 (4671636) 4671636..4672121 + 486 WP_071045790.1 antirestriction protein -
L6L58_RS22410 (4672137) 4672137..4672613 + 477 WP_001186771.1 RadC family protein -
L6L58_RS22415 (4672676) 4672676..4672897 + 222 WP_000692309.1 DUF987 domain-containing protein -
L6L58_RS22420 (4672977) 4672977..4673351 + 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
L6L58_RS22425 (4673398) 4673398..4673775 + 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
L6L58_RS22430 (4673772) 4673772..4674260 + 489 WP_000761676.1 DUF5983 family protein -
L6L58_RS22435 (4674272) 4674272..4674469 + 198 WP_000839291.1 DUF957 domain-containing protein -
L6L58_RS22440 (4674554) 4674554..4675420 + 867 WP_001280433.1 DUF4942 domain-containing protein -
L6L58_RS22445 (4675492) 4675492..4675755 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
L6L58_RS22450 (4675752) 4675752..4676078 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
L6L58_RS22455 (4676961) 4676961..4678499 + 1539 WP_061092756.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4656864..4686312 29448


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T234407 WP_000854735.1 NZ_CP091665:4673398-4673775 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T234407 NZ_LR130538:340677-341024 [Klebsiella variicola]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGGTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT234407 WP_001285415.1 NZ_CP091665:4672977-4673351 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT234407 NZ_LR130538:341024-341323 [Klebsiella variicola]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGATCCGCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACGTTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References