Detailed information of TA system TA234406

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 4481521..4482116
• Replicon: chromosome
• Accession: NZ_CP091665
• Organism: Escherichia coli strain KOr019

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: V0SXT4
• Locus tag: L6L58_RS21485
• Protein ID: WP_000239581.1
• Coordinates: 4481521..4481871 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: L4JJX7
• Locus tag: L6L58_RS21490
• Protein ID: WP_001223213.1
• Coordinates: 4481865..4482116 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6L58_RS21465 (4476975)	4476975..4477997	-	1023	WP_001361374.1	ABC transporter permease	-
L6L58_RS21470 (4478011)	4478011..4479513	-	1503	WP_001095661.1	ATP-binding cassette domain-containing protein	-
L6L58_RS21475 (4479646)	4479646..4480602	-	957	WP_000265933.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
L6L58_RS21480 (4480912)	4480912..4481442	+	531	WP_000055072.1	inorganic diphosphatase	-
L6L58_RS21485 (4481521)	4481521..4481871	-	351	WP_000239581.1	endoribonuclease toxin ChpB	Toxin
L6L58_RS21490 (4481865)	4481865..4482116	-	252	WP_001223213.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
L6L58_RS21495 (4482328)	4482328..4482669	-	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
L6L58_RS21500 (4482672)	4482672..4486451	-	3780	WP_000060873.1	autotransporter assembly complex protein TamB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12453.41 Da
• Isoelectric Point: 6.2206

>T234406 WP_000239581.1 NZ_CP091665:c4481871-4481521 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T234406 NZ_LR130538:314530-314898 [Klebsiella variicola]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCGGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9331.64 Da
• Isoelectric Point: 4.6509

>AT234406 WP_001223213.1 NZ_CP091665:c4482116-4481865 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT234406 NZ_LR130538:314312-314533 [Klebsiella variicola]
ATGAAAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: V0SXT4

Antitoxin

• AlphaFold DB: L4JJX7