Detailed information of TA system TA023439

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 4897358..4897953
• Replicon: chromosome
• Accession: NC_011750
• Organism: Escherichia coli IAI39

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: V0SXT4
• Locus tag: ECIAI39_RS23545
• Protein ID: WP_000239581.1
• Coordinates: 4897603..4897953 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: L4JJX7
• Locus tag: ECIAI39_RS23540
• Protein ID: WP_001223213.1
• Coordinates: 4897358..4897609 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECIAI39_RS23530	4893023..4896802	+	3780	WP_000060874.1	autotransporter assembly complex protein TamB	-
ECIAI39_RS23535	4896805..4897146	+	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
ECIAI39_RS23540	4897358..4897609	+	252	WP_001223213.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
ECIAI39_RS23545	4897603..4897953	+	351	WP_000239581.1	endoribonuclease toxin ChpB	Toxin
ECIAI39_RS23550	4898032..4898562	-	531	WP_000055070.1	inorganic diphosphatase	-
ECIAI39_RS23555	4898872..4899828	+	957	WP_000265942.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
ECIAI39_RS23560	4899968..4901470	+	1503	WP_000205813.1	sugar ABC transporter ATP-binding protein	-
ECIAI39_RS23565	4901484..4902506	+	1023	WP_001572298.1	ABC transporter permease	-
ECIAI39_RS23570	4902493..4902861	+	369	Protein_4603	sugar ABC transporter permease YjfF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12453.41 Da
• Isoelectric Point: 6.2206

>T23439 WP_000239581.1 NC_011750:4897603-4897953 [Escherichia coli IAI39]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T23439 NC_011750:4897603-4897953 [Escherichia coli IAI39]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGACTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9331.64 Da
• Isoelectric Point: 4.6509

>AT23439 WP_001223213.1 NC_011750:4897358-4897609 [Escherichia coli IAI39]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT23439 NC_011750:4897358-4897609 [Escherichia coli IAI39]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Toxin

• AlphaFold DB: V0SXT4

Antitoxin

• AlphaFold DB: L4JJX7