Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 945020..945818 Replicon chromosome
Accession NZ_CP091665
Organism Escherichia coli strain KOr019

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag L6L58_RS04475 Protein ID WP_000854735.1
Coordinates 945020..945397 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag L6L58_RS04480 Protein ID WP_032153712.1
Coordinates 945444..945818 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L58_RS04440 (940462) 940462..940626 + 165 WP_000065819.1 hypothetical protein -
L6L58_RS04445 (940988) 940988..942250 - 1263 WP_001218801.1 integrase arm-type DNA-binding domain-containing protein -
L6L58_RS04450 (942714) 942714..943040 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
L6L58_RS04455 (943037) 943037..943300 - 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
L6L58_RS04460 (943372) 943372..944238 - 867 WP_032153714.1 DUF4942 domain-containing protein -
L6L58_RS04465 (944323) 944323..944520 - 198 WP_000839265.1 DUF957 domain-containing protein -
L6L58_RS04470 (944532) 944532..945023 - 492 WP_023155722.1 DUF5983 family protein -
L6L58_RS04475 (945020) 945020..945397 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
L6L58_RS04480 (945444) 945444..945818 - 375 WP_032153712.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
L6L58_RS04485 (945898) 945898..946119 - 222 WP_000692345.1 DUF987 domain-containing protein -
L6L58_RS04490 (946188) 946188..946664 - 477 WP_001186715.1 RadC family protein -
L6L58_RS04495 (946680) 946680..947165 - 486 WP_032153711.1 antirestriction protein -
L6L58_RS04500 (947257) 947257..948075 - 819 WP_077064621.1 DUF932 domain-containing protein -
L6L58_RS04505 (948166) 948166..948375 - 210 WP_023155727.1 DUF905 family protein -
L6L58_RS04510 (948405) 948405..949082 - 678 WP_001097301.1 hypothetical protein -
L6L58_RS04515 (949230) 949230..949910 - 681 WP_077064622.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island sul2 / ant(3'')-Ia / aac(3)-VIa / qacE / sul1 / blaCTX-M-2 htpB 928028..1019755 91727


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T234385 WP_000854735.1 NZ_CP091665:c945397-945020 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T234385 NZ_LR130534:2486043-2486618 [Pseudomonas aeruginosa]
ATGAGGCATTCCCCCTTCACGGCCGTCTACGACGCATGCGTTCTCTATCCCGCTCCGCTGCGGGACTTCCTGATGTGGCT
GGGGCTGTCCGGTCGGTTCCGAGCGCGTTGGAGCCAAACCATTCACGAGGAGTGGAAACGCAACCTGCTGATCAATCGGC
CCGATCTCACCAGGGCGCAAGTTGACCGAACGTCTGACCTGATGGATCGTGCCATCCCCGATGGATTGGTAGAAGGGTAC
GAATCGCTCGCGGCCGGTCTGACCTTGCCAGATCCGGACGACCGCCACGTGCTGGCCGCCGCCATTCGCTGTGGGGCGAG
TGTGATCGTGACATTCAACCAGCGAGATTTCCCGAATGAGCTGCTGGCGCCCTACGGCGTCGAATCGCAGCATCCGGATG
AGTTCGTGGACAACTTGCTGGATCTGGATGCGGCTGCAGTCGTCTCGGCCGCACAGCGCCAGCGCGCCCAACTGAGGAAC
CCGACGATCGACGTCGATCGCTATCTCGATATCTTGCTGCGCCAAGGCCTGGTCCAGACCACCAAGGTGCTTGCCGGCTA
CCGCACTATCCTCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT234385 WP_032153712.1 NZ_CP091665:c945818-945444 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT234385 NZ_LR130534:2485579-2486046 [Pseudomonas aeruginosa]
ATGACCGTTACTGCCCAATCCAAGATGACTCTGCCCGCCGAGGGTGAGGTGAAGGCAGCCGTGCAGGGGCAACGCGCCTT
GGCTGCCTACCTCGCGACGCAGTTTGAAACTCAGCACATCCAGATTTTCGATGACCAGAAGCAGGCACACCAAGTCGAGC
TGCCGACCTCGGCTTTGCGTTTGTTGGTGGACATCTTGGCCGAACTGGCCGACGGCAATGCTGTGAAGGTGGTGCCTGTC
CATGCCGAGCTGACAACACAGGAGGCCGCGGACCTGCTCAACGTGTCCCGTCCGCATTTCGTCAAGCTGCTCGAAGATGG
GGTGTTGGCGTTTCATCGGACTGGCAAGCACCGCCGGGTGAGGTTTGCCGACCTGATGCAGTACAAGGAGGCGCGTGAGC
GCGCCAGCGAGCAGGCGATGGCTGAACTCACACAGCAGTCGCAAGAGTTGGGAATGGGGTACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References