Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 977300..977954 Replicon chromosome
Accession NZ_CP091664
Organism Escherichia coli strain KKa019

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag L6L56_RS04740 Protein ID WP_000244781.1
Coordinates 977547..977954 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0V9GG32
Locus tag L6L56_RS04735 Protein ID WP_001564007.1
Coordinates 977300..977566 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L56_RS04715 (973388) 973388..974821 - 1434 WP_001564009.1 6-phospho-beta-glucosidase BglA -
L6L56_RS04720 (974866) 974866..975177 + 312 WP_001182966.1 N(4)-acetylcytidine aminohydrolase -
L6L56_RS04725 (975341) 975341..976000 + 660 WP_000250274.1 hemolysin III family protein -
L6L56_RS04730 (976077) 976077..977057 - 981 WP_001564008.1 tRNA-modifying protein YgfZ -
L6L56_RS04735 (977300) 977300..977566 + 267 WP_001564007.1 FAD assembly factor SdhE Antitoxin
L6L56_RS04740 (977547) 977547..977954 + 408 WP_000244781.1 protein YgfX Toxin
L6L56_RS04745 (977994) 977994..978515 - 522 WP_001055874.1 flavodoxin FldB -
L6L56_RS04750 (978627) 978627..979523 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
L6L56_RS04755 (979548) 979548..980258 + 711 WP_001564005.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L6L56_RS04760 (980264) 980264..981997 + 1734 WP_001564004.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T234358 WP_000244781.1 NZ_CP091664:977547-977954 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T234358 NZ_LR130532:c2078384-2078277 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10565.15 Da        Isoelectric Point: 5.1599

>AT234358 WP_001564007.1 NZ_CP091664:977300-977566 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWMMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT234358 NZ_LR130532:2078432-2078498 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9GG32

References