234352

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3998019..3998854 Replicon chromosome
Accession NZ_CP091662
Organism Escherichia coli strain KFu023

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J2AEA6
Locus tag L6L71_RS19255 Protein ID WP_000854759.1
Coordinates 3998019..3998396 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag L6L71_RS19260 Protein ID WP_001295723.1
Coordinates 3998486..3998854 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L71_RS19225 (3993647) 3993647..3994393 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
L6L71_RS19230 (3994408) 3994408..3995949 - 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
L6L71_RS19235 (3996543) 3996543..3996719 - 177 Protein_3776 helix-turn-helix domain-containing protein -
L6L71_RS19240 (3997086) 3997086..3997235 - 150 Protein_3777 hypothetical protein -
L6L71_RS19245 (3997341) 3997341..3997517 - 177 WP_000839286.1 DUF957 domain-containing protein -
L6L71_RS19250 (3997534) 3997534..3998022 - 489 WP_000761690.1 DUF5983 family protein -
L6L71_RS19255 (3998019) 3998019..3998396 - 378 WP_000854759.1 TA system toxin CbtA family protein Toxin
L6L71_RS19260 (3998486) 3998486..3998854 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
L6L71_RS19265 (3999017) 3999017..3999238 - 222 WP_000692345.1 DUF987 domain-containing protein -
L6L71_RS19270 (3999301) 3999301..3999777 - 477 WP_001186775.1 RadC family protein -
L6L71_RS19275 (3999793) 3999793..4000266 - 474 WP_001350782.1 antirestriction protein -
L6L71_RS19280 (4000608) 4000608..4001426 - 819 WP_001234651.1 DUF932 domain-containing protein -
L6L71_RS19285 (4001544) 4001544..4001739 - 196 Protein_3786 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3990428..4045428 55000


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14144.26 Da        Isoelectric Point: 7.3249

>T234352 WP_000854759.1 NZ_CP091662:c3998396-3998019 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T234352 NZ_LR130532:381701-381874 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT234352 WP_001295723.1 NZ_CP091662:c3998854-3998486 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT234352 NZ_LR130532:381377-381673 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CTTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2AEA6

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References