Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3964134..3964948 Replicon chromosome
Accession NZ_CP091662
Organism Escherichia coli strain KFu023

Toxin (Protein)


Gene name yjhX Uniprot ID A0A6C9SL90
Locus tag L6L71_RS19090 Protein ID WP_001054375.1
Coordinates 3964134..3964391 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag L6L71_RS19095 Protein ID WP_001309181.1
Coordinates 3964403..3964948 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L71_RS19065 (3959816) 3959816..3960796 + 981 WP_000991455.1 sialate O-acetylesterase -
L6L71_RS19075 (3961775) 3961775..3961888 + 114 Protein_3744 HNH endonuclease -
L6L71_RS19080 (3962156) 3962156..3963396 - 1241 Protein_3745 helicase YjhR -
L6L71_RS19085 (3963512) 3963512..3963643 + 132 WP_001309182.1 hypothetical protein -
L6L71_RS19090 (3964134) 3964134..3964391 + 258 WP_001054375.1 YjhX family toxin Toxin
L6L71_RS19095 (3964403) 3964403..3964948 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
L6L71_RS19100 (3965004) 3965004..3965750 + 747 WP_000354252.1 class I SAM-dependent methyltransferase -
L6L71_RS19105 (3965919) 3965919..3966137 + 219 Protein_3750 hypothetical protein -
L6L71_RS19110 (3966175) 3966175..3966291 + 117 Protein_3751 VOC family protein -
L6L71_RS19115 (3966536) 3966536..3967657 + 1122 WP_000010831.1 M42 family metallopeptidase -
L6L71_RS19120 (3967654) 3967654..3967932 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
L6L71_RS19125 (3967944) 3967944..3969257 + 1314 WP_000460845.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9768.31 Da        Isoelectric Point: 11.0090

>T234351 WP_001054375.1 NZ_CP091662:3964134-3964391 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QFDNR

Download         Length: 258 bp

>T234351 NZ_LR130532:106543-106854 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTATTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19938.86 Da        Isoelectric Point: 6.3277

>AT234351 WP_001309181.1 NZ_CP091662:3964403-3964948 [Escherichia coli]
ITVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT234351 NZ_LR130532:106855-107145 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C9SL90

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References