Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 4512971..4513609 Replicon chromosome
Accession NZ_CP091659
Organism Escherichia coli strain KFu024

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag L6L61_RS22995 Protein ID WP_000813794.1
Coordinates 4513433..4513609 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L6L61_RS22990 Protein ID WP_001270286.1
Coordinates 4512971..4513387 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L61_RS22970 (4508123) 4508123..4509064 - 942 WP_001251313.1 ABC transporter permease -
L6L61_RS22975 (4509065) 4509065..4510078 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
L6L61_RS22980 (4510096) 4510096..4511241 - 1146 WP_096037851.1 ABC transporter substrate-binding protein -
L6L61_RS22985 (4511486) 4511486..4512892 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
L6L61_RS22990 (4512971) 4512971..4513387 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
L6L61_RS22995 (4513433) 4513433..4513609 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
L6L61_RS23000 (4513831) 4513831..4514061 + 231 WP_000494244.1 YncJ family protein -
L6L61_RS23005 (4514153) 4514153..4516114 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
L6L61_RS23010 (4516187) 4516187..4516723 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
L6L61_RS23015 (4516815) 4516815..4517990 + 1176 WP_001236261.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T234329 WP_000813794.1 NZ_CP091659:c4513609-4513433 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T234329 NZ_LR130518:c2604752-2604486 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT234329 WP_001270286.1 NZ_CP091659:c4513387-4512971 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT234329 NZ_LR130518:c2605009-2604752 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References