Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3858382..3859217 Replicon chromosome
Accession NZ_CP091659
Organism Escherichia coli strain KFu024

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2T3T4L0
Locus tag L6L61_RS19390 Protein ID WP_001556084.1
Coordinates 3858382..3858759 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A403D757
Locus tag L6L61_RS19395 Protein ID WP_016230789.1
Coordinates 3858849..3859217 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L61_RS19355 (3853902) 3853902..3854375 + 474 WP_001105407.1 DNA gyrase inhibitor SbmC -
L6L61_RS19360 (3854573) 3854573..3855631 + 1059 WP_001200895.1 FUSC family protein -
L6L61_RS19365 (3855803) 3855803..3856132 + 330 WP_000450409.1 DUF496 family protein -
L6L61_RS19370 (3856233) 3856233..3856598 - 366 WP_001280454.1 EutP/PduV family microcompartment system protein -
L6L61_RS19375 (3856869) 3856869..3857258 - 390 WP_102804527.1 transposase -
L6L61_RS19380 (3858056) 3858056..3858136 - 81 Protein_3619 hypothetical protein -
L6L61_RS19385 (3858236) 3858236..3858385 - 150 Protein_3620 DUF5983 family protein -
L6L61_RS19390 (3858382) 3858382..3858759 - 378 WP_001556084.1 TA system toxin CbtA family protein Toxin
L6L61_RS19395 (3858849) 3858849..3859217 - 369 WP_016230789.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
L6L61_RS19400 (3859380) 3859380..3859601 - 222 WP_000692345.1 DUF987 domain-containing protein -
L6L61_RS19405 (3859664) 3859664..3860140 - 477 WP_001186775.1 RadC family protein -
L6L61_RS19410 (3860156) 3860156..3860629 - 474 WP_001765426.1 antirestriction protein -
L6L61_RS19415 (3860971) 3860971..3861789 - 819 WP_020239663.1 DUF932 domain-containing protein -
L6L61_RS19420 (3861907) 3861907..3862102 - 196 Protein_3627 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14232.27 Da        Isoelectric Point: 7.8276

>T234319 WP_001556084.1 NZ_CP091659:c3858759-3858382 [Escherichia coli]
MKTLPDTHVRELSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T234319 NZ_LR130515:c2744761-2744495 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13614.45 Da        Isoelectric Point: 7.0264

>AT234319 WP_016230789.1 NZ_CP091659:c3859217-3858849 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT234319 NZ_LR130515:c2745018-2744761 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T3T4L0

Antitoxin

Source ID Structure
AlphaFold DB A0A403D757

References