Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2605799..2606394 Replicon chromosome
Accession NZ_CP091659
Organism Escherichia coli strain KFu024

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag L6L61_RS13520 Protein ID WP_000239579.1
Coordinates 2606044..2606394 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag L6L61_RS13515 Protein ID WP_001223208.1
Coordinates 2605799..2606050 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L61_RS13505 (2601464) 2601464..2605243 + 3780 WP_000060901.1 autotransporter assembly complex protein TamB -
L6L61_RS13510 (2605246) 2605246..2605587 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
L6L61_RS13515 (2605799) 2605799..2606050 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
L6L61_RS13520 (2606044) 2606044..2606394 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
L6L61_RS13525 (2606474) 2606474..2607004 - 531 WP_000055072.1 inorganic diphosphatase -
L6L61_RS13530 (2607314) 2607314..2608270 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
L6L61_RS13535 (2608434) 2608434..2609912 + 1479 WP_231838809.1 sugar ABC transporter ATP-binding protein -
L6L61_RS13540 (2609926) 2609926..2610948 + 1023 WP_001295197.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T234312 WP_000239579.1 NZ_CP091659:2606044-2606394 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T234312 NZ_LR130515:c2118662-2118486 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT234312 WP_001223208.1 NZ_CP091659:2605799-2606050 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT234312 NZ_LR130515:2118363-2118418 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References