Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2445984..2446782 Replicon chromosome
Accession NZ_CP091659
Organism Escherichia coli strain KFu024

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag L6L61_RS12675 Protein ID WP_000854735.1
Coordinates 2445984..2446361 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag L6L61_RS12680 Protein ID WP_032153712.1
Coordinates 2446408..2446782 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L61_RS12645 (2441257) 2441257..2442795 - 1539 Protein_2293 lysine decarboxylation/transport transcriptional activator CadC -
L6L61_RS12650 (2443678) 2443678..2444004 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
L6L61_RS12655 (2444001) 2444001..2444264 - 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
L6L61_RS12660 (2444336) 2444336..2445202 - 867 WP_032153714.1 DUF4942 domain-containing protein -
L6L61_RS12665 (2445287) 2445287..2445484 - 198 WP_000839265.1 DUF957 domain-containing protein -
L6L61_RS12670 (2445496) 2445496..2445987 - 492 WP_023155722.1 DUF5983 family protein -
L6L61_RS12675 (2445984) 2445984..2446361 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
L6L61_RS12680 (2446408) 2446408..2446782 - 375 WP_032153712.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
L6L61_RS12685 (2446862) 2446862..2447083 - 222 WP_000692345.1 DUF987 domain-containing protein -
L6L61_RS12690 (2447152) 2447152..2447628 - 477 WP_001186715.1 RadC family protein -
L6L61_RS12695 (2447644) 2447644..2448129 - 486 WP_032153711.1 antirestriction protein -
L6L61_RS12700 (2448221) 2448221..2449039 - 819 WP_001234693.1 DUF932 domain-containing protein -
L6L61_RS12705 (2449130) 2449130..2449339 - 210 WP_023155727.1 DUF905 family protein -
L6L61_RS12710 (2449369) 2449369..2450046 - 678 WP_023155728.1 hypothetical protein -
L6L61_RS12715 (2450165) 2450165..2451049 - 885 WP_024166630.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T234311 WP_000854735.1 NZ_CP091659:c2446361-2445984 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T234311 NZ_LR130515:c2016002-2015850 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT234311 WP_032153712.1 NZ_CP091659:c2446782-2446408 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT234311 NZ_LR130515:c2016626-2016027 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References