Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1703342..1703973 Replicon chromosome
Accession NZ_CP091659
Organism Escherichia coli strain KFu024

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag L6L61_RS09255 Protein ID WP_001259385.1
Coordinates 1703698..1703973 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag L6L61_RS09250 Protein ID WP_000593554.1
Coordinates 1703342..1703701 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L61_RS09220 (1698454) 1698454..1698927 + 474 WP_001161553.1 PTS sugar transporter subunit IIA -
L6L61_RS09225 (1698924) 1698924..1699205 + 282 WP_000084022.1 PTS sugar transporter subunit IIB -
L6L61_RS09230 (1699282) 1699282..1700640 + 1359 WP_169772856.1 PTS galactitol transporter subunit IIC -
L6L61_RS09235 (1700633) 1700633..1702141 + 1509 WP_001298718.1 FGGY-family carbohydrate kinase -
L6L61_RS09240 (1702131) 1702131..1702400 + 270 WP_000933060.1 HPr family phosphocarrier protein -
L6L61_RS09245 (1702432) 1702432..1703292 + 861 WP_001131783.1 class II aldolase -
L6L61_RS09250 (1703342) 1703342..1703701 - 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L6L61_RS09255 (1703698) 1703698..1703973 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
L6L61_RS09260 (1704046) 1704046..1705170 - 1125 WP_001314210.1 ABC transporter permease -
L6L61_RS09265 (1705170) 1705170..1707905 - 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -
L6L61_RS09270 (1707902) 1707902..1708969 - 1068 WP_000361467.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T234309 WP_001259385.1 NZ_CP091659:c1703973-1703698 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T234309 NZ_LR130515:960888-961181 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAAGTGTACTTAAAAGAGTTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCGTCACTTCAAGCCGATCAAAGCGAAAGTAACGCATAG

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT234309 WP_000593554.1 NZ_CP091659:c1703701-1703342 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT234309 NZ_LR130515:960676-960885 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References