Detailed information of TA system TA234302

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 349489..350194
• Replicon: chromosome
• Accession: NZ_CP091659
• Organism: Escherichia coli strain KFu024

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: L6L61_RS02600
• Protein ID: WP_000539521.1
• Coordinates: 349489..349875 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: L6L61_RS02605
• Protein ID: WP_001280945.1
• Coordinates: 349865..350194 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6L61_RS02580 (345493)	345493..346119	+	627	WP_001295292.1	glutathione S-transferase GstB	-
L6L61_RS02585 (346116)	346116..347231	-	1116	Protein_342	aldose sugar dehydrogenase YliI	-
L6L61_RS02590 (347342)	347342..347725	-	384	WP_000497137.1	biofilm formation regulator BssR	-
L6L61_RS02595 (347938)	347938..349263	+	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
L6L61_RS02600 (349489)	349489..349875	+	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L6L61_RS02605 (349865)	349865..350194	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
L6L61_RS02610 (350264)	350264..351592	-	1329	WP_000086877.1	GGDEF domain-containing protein	-
L6L61_RS02615 (351600)	351600..353948	-	2349	WP_096038021.1	EAL domain-containing protein	-
L6L61_RS02620 (354126)	354126..355037	-	912	WP_001236042.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T234302 WP_000539521.1 NZ_CP091659:349489-349875 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T234302 NZ_LR130513:c2142111-2141749 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATTATTCAAAATGACACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAATATAAATTGGATAAAGACTCAGTCATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTATTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT234302 WP_001280945.1 NZ_CP091659:349865-350194 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT234302 NZ_LR130513:c2142278-2142108 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAATCATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Toxin

• AlphaFold DB: A0A829GCT6