234267

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3859058..3859676 Replicon chromosome
Accession NZ_CP091652
Organism Escherichia coli strain KMi025

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag L6L63_RS18710 Protein ID WP_001291435.1
Coordinates 3859058..3859276 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag L6L63_RS18715 Protein ID WP_000344800.1
Coordinates 3859302..3859676 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L63_RS18675 (3854347) 3854347..3854919 + 573 WP_000779831.1 YbaY family lipoprotein -
L6L63_RS18680 (3854950) 3854950..3855261 - 312 WP_000409911.1 MGMT family protein -
L6L63_RS18690 (3855640) 3855640..3855993 + 354 WP_000878140.1 DUF1428 domain-containing protein -
L6L63_RS18695 (3856035) 3856035..3857585 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
L6L63_RS18700 (3857749) 3857749..3858219 - 471 WP_000136192.1 YlaC family protein -
L6L63_RS18705 (3858335) 3858335..3858886 - 552 WP_000102564.1 maltose O-acetyltransferase -
L6L63_RS18710 (3859058) 3859058..3859276 - 219 WP_001291435.1 HHA domain-containing protein Toxin
L6L63_RS18715 (3859302) 3859302..3859676 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
L6L63_RS18720 (3860222) 3860222..3863371 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
L6L63_RS18725 (3863394) 3863394..3864587 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T234267 WP_001291435.1 NZ_CP091652:c3859276-3859058 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T234267 NZ_LR129843:c1583719-1583540 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTAAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT234267 WP_000344800.1 NZ_CP091652:c3859676-3859302 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT234267 NZ_LR129843:c1583503-1583051 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGCTAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References