Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1831075..1831873 Replicon chromosome
Accession NZ_CP091652
Organism Escherichia coli strain KMi025

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag L6L63_RS08930 Protein ID WP_000854735.1
Coordinates 1831496..1831873 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag L6L63_RS08925 Protein ID WP_001285415.1
Coordinates 1831075..1831449 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L63_RS08890 (1827007) 1827007..1827687 + 681 WP_001282919.1 WYL domain-containing protein -
L6L63_RS08895 (1827835) 1827835..1828512 + 678 WP_001097302.1 hypothetical protein -
L6L63_RS08900 (1828518) 1828518..1828751 + 234 WP_001278287.1 DUF905 family protein -
L6L63_RS08905 (1828841) 1828841..1829659 + 819 WP_001175148.1 DUF932 domain-containing protein -
L6L63_RS08910 (1829741) 1829741..1830219 + 479 Protein_1744 antirestriction protein -
L6L63_RS08915 (1830235) 1830235..1830711 + 477 WP_001366855.1 RadC family protein -
L6L63_RS08920 (1830774) 1830774..1830995 + 222 WP_000692309.1 DUF987 domain-containing protein -
L6L63_RS08925 (1831075) 1831075..1831449 + 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
L6L63_RS08930 (1831496) 1831496..1831873 + 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
L6L63_RS08935 (1831870) 1831870..1832358 + 489 WP_000761676.1 DUF5983 family protein -
L6L63_RS08940 (1832370) 1832370..1832567 + 198 WP_000839291.1 DUF957 domain-containing protein -
L6L63_RS08945 (1832652) 1832652..1833518 + 867 WP_001280433.1 DUF4942 domain-containing protein -
L6L63_RS08950 (1833590) 1833590..1833853 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
L6L63_RS08955 (1833850) 1833850..1834176 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
L6L63_RS08960 (1834640) 1834640..1835902 + 1263 WP_032161224.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1798045..1885881 87836


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T234259 WP_000854735.1 NZ_CP091652:1831496-1831873 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T234259 NZ_LR129840:c1202828-1202574 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGGCCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT234259 WP_001285415.1 NZ_CP091652:1831075-1831449 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT234259 NZ_LR129840:c1203072-1202830 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References