234254

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 284594..285232 Replicon chromosome
Accession NZ_CP091652
Organism Escherichia coli strain KMi025

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag L6L63_RS01430 Protein ID WP_001447010.1
Coordinates 285056..285232 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L6L63_RS01425 Protein ID WP_001270286.1
Coordinates 284594..285010 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L63_RS01405 (279746) 279746..280687 - 942 WP_001251304.1 ABC transporter permease -
L6L63_RS01410 (280688) 280688..281701 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
L6L63_RS01415 (281719) 281719..282864 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
L6L63_RS01420 (283109) 283109..284515 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
L6L63_RS01425 (284594) 284594..285010 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
L6L63_RS01430 (285056) 285056..285232 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
L6L63_RS01435 (285454) 285454..285684 + 231 WP_000494244.1 YncJ family protein -
L6L63_RS01440 (285776) 285776..287737 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
L6L63_RS01445 (287810) 287810..288346 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
L6L63_RS01450 (288438) 288438..289613 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T234254 WP_001447010.1 NZ_CP091652:c285232-285056 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T234254 NZ_LR027878:c2715921-2715814 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT234254 WP_001270286.1 NZ_CP091652:c285010-284594 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT234254 NZ_LR027878:2715737-2715797 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References