Detailed information of TA system TA234246

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4031073..4032762
• Replicon: chromosome
• Accession: NZ_CP091651
• Organism: Escherichia coli strain KTa008

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: V0Z9M0
• Locus tag: L6L70_RS19505
• Protein ID: WP_000365809.1
• Coordinates: 4031073..4031993 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: L6L70_RS19510
• Protein ID: WP_001550661.1
• Coordinates: 4031980..4032762 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6L70_RS19490 (4027163)	4027163..4028290	-	1128	WP_001550663.1	MFS transporter	-
L6L70_RS19495 (4028432)	4028432..4029490	-	1059	WP_122987197.1	alpha/beta hydrolase	-
L6L70_RS19500 (4029755)	4029755..4030639	+	885	WP_001119037.1	LysR family transcriptional regulator	-
L6L70_RS19505 (4031073)	4031073..4031993	-	921	WP_000365809.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
L6L70_RS19510 (4031980)	4031980..4032762	-	783	WP_001550661.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
L6L70_RS19515 (4033078)	4033078..4036287	+	3210	WP_001521910.1	RNA-directed DNA polymerase	-
L6L70_RS19520 (4036634)	4036634..4037104	+	471	WP_000201185.1	hypothetical protein	-
L6L70_RS19525 (4037101)	4037101..4037203	+	103	Protein_3837	helix-turn-helix domain-containing protein	-
L6L70_RS19530 (4037295)	4037295..4037453	+	159	Protein_3838	integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-261)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-247)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34571.01 Da
• Isoelectric Point: 7.2649

>T234246 WP_000365809.1 NZ_CP091651:c4031993-4031073 [Escherichia coli]
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA

Nucleotide

• Length: 921 bp

>T234246 NZ_LR027878:1959503-1959598 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29191.43 Da
• Isoelectric Point: 8.9059

>AT234246 WP_001550661.1 NZ_CP091651:c4032762-4031980 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEQGKPQVWLALPAYVKLPGWFSAFEQSATFVTLYTSGLTADVTPFTTELKIGDRQLAGSVPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSVKTNRVMLYLARRNGHPYFQYIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

>AT234246 NZ_LR027878:c1959685-1959626 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Toxin

• AlphaFold DB: V0Z9M0