Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3827187..3827805 Replicon chromosome
Accession NZ_CP091651
Organism Escherichia coli strain KTa008

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag L6L70_RS18555 Protein ID WP_001291435.1
Coordinates 3827587..3827805 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag L6L70_RS18550 Protein ID WP_000344800.1
Coordinates 3827187..3827561 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L70_RS18540 (3822276) 3822276..3823469 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L6L70_RS18545 (3823492) 3823492..3826641 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
L6L70_RS18550 (3827187) 3827187..3827561 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
L6L70_RS18555 (3827587) 3827587..3827805 + 219 WP_001291435.1 HHA domain-containing protein Toxin
L6L70_RS18560 (3827977) 3827977..3828528 + 552 WP_060579167.1 maltose O-acetyltransferase -
L6L70_RS18565 (3828644) 3828644..3829114 + 471 WP_000136192.1 YlaC family protein -
L6L70_RS18570 (3829278) 3829278..3830828 + 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
L6L70_RS18575 (3830870) 3830870..3831223 - 354 WP_001550741.1 DUF1428 family protein -
L6L70_RS18585 (3831602) 3831602..3831913 + 312 WP_000409911.1 MGMT family protein -
L6L70_RS18590 (3831944) 3831944..3832516 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T234245 WP_001291435.1 NZ_CP091651:3827587-3827805 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T234245 NZ_LR027878:959574-959867 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAAGTGTACTTAAAAGAGTTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCGTCACTTCAAGCCGATCAAAGCGAAAGTAACGCATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT234245 WP_000344800.1 NZ_CP091651:3827187-3827561 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT234245 NZ_LR027878:959362-959571 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References