Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 991657..992311 Replicon chromosome
Accession NZ_CP091651
Organism Escherichia coli strain KTa008

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag L6L70_RS04815 Protein ID WP_000244781.1
Coordinates 991904..992311 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0V9GG32
Locus tag L6L70_RS04810 Protein ID WP_001564007.1
Coordinates 991657..991923 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L70_RS04790 (987745) 987745..989178 - 1434 WP_001564009.1 6-phospho-beta-glucosidase BglA -
L6L70_RS04795 (989223) 989223..989534 + 312 WP_001182966.1 N(4)-acetylcytidine aminohydrolase -
L6L70_RS04800 (989698) 989698..990357 + 660 WP_000250274.1 hemolysin III family protein -
L6L70_RS04805 (990434) 990434..991414 - 981 WP_001564008.1 tRNA-modifying protein YgfZ -
L6L70_RS04810 (991657) 991657..991923 + 267 WP_001564007.1 FAD assembly factor SdhE Antitoxin
L6L70_RS04815 (991904) 991904..992311 + 408 WP_000244781.1 protein YgfX Toxin
L6L70_RS04820 (992351) 992351..992872 - 522 WP_001055874.1 flavodoxin FldB -
L6L70_RS04825 (992984) 992984..993880 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
L6L70_RS04830 (993905) 993905..994615 + 711 WP_001564005.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L6L70_RS04835 (994621) 994621..996354 + 1734 WP_001564004.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T234228 WP_000244781.1 NZ_CP091651:991904-992311 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T234228 NZ_LR027876:c2300923-2300819 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10565.15 Da        Isoelectric Point: 5.1599

>AT234228 WP_001564007.1 NZ_CP091651:991657-991923 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWMMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT234228 NZ_LR027876:2300706-2300761 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9GG32

References