Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 843458..844293 | Replicon | chromosome |
| Accession | NZ_CP091651 | ||
| Organism | Escherichia coli strain KTa008 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0A1A9A5 |
| Locus tag | L6L70_RS04030 | Protein ID | WP_001564063.1 |
| Coordinates | 843458..843835 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0K5N986 |
| Locus tag | L6L70_RS04035 | Protein ID | WP_021553056.1 |
| Coordinates | 843925..844293 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L6L70_RS04000 (838863) | 838863..839270 | - | 408 | Protein_783 | IS5-like element IS903B family transposase | - |
| L6L70_RS04005 (839350) | 839350..840225 | - | 876 | WP_001617865.1 | extended-spectrum class A beta-lactamase CTX-M-14 | - |
| L6L70_RS04010 (840475) | 840475..841737 | - | 1263 | WP_000608644.1 | IS1380-like element ISEcp1 family transposase | - |
| L6L70_RS04015 (842112) | 842112..842954 | - | 843 | Protein_786 | DUF4942 domain-containing protein | - |
| L6L70_RS04020 (843039) | 843039..843233 | - | 195 | WP_024181941.1 | DUF957 domain-containing protein | - |
| L6L70_RS04025 (843312) | 843312..843461 | - | 150 | Protein_788 | DUF5983 family protein | - |
| L6L70_RS04030 (843458) | 843458..843835 | - | 378 | WP_001564063.1 | TA system toxin CbtA family protein | Toxin |
| L6L70_RS04035 (843925) | 843925..844293 | - | 369 | WP_021553056.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| L6L70_RS04040 (844456) | 844456..844677 | - | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| L6L70_RS04045 (844742) | 844742..845218 | - | 477 | WP_021553055.1 | RadC family protein | - |
| L6L70_RS04050 (845234) | 845234..845713 | - | 480 | WP_001564060.1 | antirestriction protein | - |
| L6L70_RS04055 (845979) | 845979..846797 | - | 819 | WP_001564059.1 | DUF932 domain-containing protein | - |
| L6L70_RS04060 (846887) | 846887..847120 | - | 234 | WP_001278293.1 | DUF905 family protein | - |
| L6L70_RS04065 (847126) | 847126..847803 | - | 678 | WP_001564058.1 | hypothetical protein | - |
| L6L70_RS04070 (847954) | 847954..848634 | - | 681 | WP_001278649.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | papX | 841985..915589 | 73604 | |
| - | flank | IS/Tn | blaCTX-M-14 | - | 839350..841737 | 2387 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14094.09 Da Isoelectric Point: 7.8045
>T234227 WP_001564063.1 NZ_CP091651:c843835-843458 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ
Download Length: 378 bp
>T234227 NZ_LR027876:c2243558-2243349 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG
Antitoxin
Download Length: 123 a.a. Molecular weight: 13615.39 Da Isoelectric Point: 7.0264
>AT234227 WP_021553056.1 NZ_CP091651:c844293-843925 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGNRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGNRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT234227 NZ_LR027876:c2243863-2243570 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0A1A9A5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K5N986 |