Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3596041..3596698 Replicon chromosome
Accession NZ_CP091650
Organism Klebsiella pneumoniae strain TAKPN-1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag L6D56_RS17440 Protein ID WP_002916310.1
Coordinates 3596288..3596698 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag L6D56_RS17435 Protein ID WP_002916312.1
Coordinates 3596041..3596307 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6D56_RS17410 3591249..3592682 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
L6D56_RS17415 3592801..3593529 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
L6D56_RS17420 3593579..3593890 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
L6D56_RS17425 3594054..3594713 + 660 WP_002916317.1 hemolysin III family protein -
L6D56_RS17430 3594812..3595795 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
L6D56_RS17435 3596041..3596307 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
L6D56_RS17440 3596288..3596698 + 411 WP_002916310.1 protein YgfX Toxin
L6D56_RS17445 3596705..3597226 - 522 WP_004144730.1 flavodoxin FldB -
L6D56_RS17450 3597327..3598223 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
L6D56_RS17455 3598246..3598959 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L6D56_RS17460 3598965..3600698 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T234216 WP_002916310.1 NZ_CP091650:3596288-3596698 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T234216 NZ_LR027874:c2316559-2316350 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT234216 WP_002916312.1 NZ_CP091650:3596041-3596307 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT234216 NZ_LR027874:c2316864-2316571 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References