Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2214447..2214963 Replicon chromosome
Accession NZ_CP091650
Organism Klebsiella pneumoniae strain TAKPN-1

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag L6D56_RS10735 Protein ID WP_002886902.1
Coordinates 2214447..2214731 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag L6D56_RS10740 Protein ID WP_002886901.1
Coordinates 2214721..2214963 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6D56_RS10710 2209864..2210127 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
L6D56_RS10715 2210257..2210430 + 174 WP_032410138.1 hypothetical protein -
L6D56_RS10720 2210433..2211176 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
L6D56_RS10725 2211533..2213671 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
L6D56_RS10730 2213979..2214443 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L6D56_RS10735 2214447..2214731 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L6D56_RS10740 2214721..2214963 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L6D56_RS10745 2215041..2216951 - 1911 WP_004152270.1 PRD domain-containing protein -
L6D56_RS10750 2216974..2218128 - 1155 WP_002886900.1 lactonase family protein -
L6D56_RS10755 2218195..2218935 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T234210 WP_002886902.1 NZ_CP091650:c2214731-2214447 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T234210 NZ_LR027874:921293-921586 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAAGTGTACTTAAAAGAGTTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCGTCACTTCAAGCCGACCAAAGCGAAAGTAACGCATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT234210 WP_002886901.1 NZ_CP091650:c2214963-2214721 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT234210 NZ_LR027874:921081-921290 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References