Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 2133283..2133975 Replicon chromosome
Accession NZ_CP091650
Organism Klebsiella pneumoniae strain TAKPN-1

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag L6D56_RS10390 Protein ID WP_071603219.1
Coordinates 2133283..2133624 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag L6D56_RS10395 Protein ID WP_040189932.1
Coordinates 2133649..2133975 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6D56_RS10365 2129191..2130645 - 1455 WP_074184809.1 serine protease -
L6D56_RS10370 2130833..2131630 - 798 WP_038806919.1 helix-turn-helix transcriptional regulator -
L6D56_RS10375 2131731..2132006 - 276 Protein_2040 type II toxin-antitoxin system RelE/ParE family toxin -
L6D56_RS10380 2132010..2132258 - 249 WP_038806909.1 ribbon-helix-helix domain-containing protein -
L6D56_RS10385 2132335..2133168 - 834 WP_038806910.1 DUF4942 domain-containing protein -
L6D56_RS10390 2133283..2133624 - 342 WP_071603219.1 TA system toxin CbtA family protein Toxin
L6D56_RS10395 2133649..2133975 - 327 WP_040189932.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
L6D56_RS10400 2133989..2134465 - 477 WP_038806912.1 DNA repair protein RadC -
L6D56_RS10405 2134476..2134922 - 447 WP_038806913.1 antirestriction protein -
L6D56_RS10410 2135146..2135835 - 690 WP_038806914.1 hypothetical protein -
L6D56_RS10415 2136155..2136508 + 354 WP_038806915.1 hypothetical protein -
L6D56_RS10420 2136545..2137435 - 891 WP_038806917.1 YfjP family GTPase -
L6D56_RS10425 2137533..2138798 + 1266 WP_038806918.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2116769..2156165 39396


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12762.63 Da        Isoelectric Point: 7.8846

>T234209 WP_071603219.1 NZ_CP091650:c2133624-2133283 [Klebsiella pneumoniae]
MKTIPATTQRAAKSCPSPVAFWQMPLTRLLEQHYGLTLNDTPFSDETAIQEHINAGITLVDAVNFLVEKYELVRIDRRGF
NCQEQSPYLGAVDILRARQVTGLLRQSPHPSIR

Download         Length: 342 bp

>T234209 NZ_LR027874:c897466-897278 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12333.06 Da        Isoelectric Point: 6.9560

>AT234209 WP_040189932.1 NZ_CP091650:c2133975-2133649 [Klebsiella pneumoniae]
MPLTDAIQWGLKRSFTPNFGARLVQEGNRLHYLADRANITGKFVDAECQKLEEAFPHFIRQMELMLSTGELNPRHAHSVT
LYHNAFTCEADTLGSCGYVYIVIYPTQR

Download         Length: 327 bp

>AT234209 NZ_LR027874:c897755-897495 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References