Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1464374..1464993 Replicon chromosome
Accession NZ_CP091650
Organism Klebsiella pneumoniae strain TAKPN-1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag L6D56_RS07150 Protein ID WP_002892050.1
Coordinates 1464775..1464993 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag L6D56_RS07145 Protein ID WP_002892066.1
Coordinates 1464374..1464748 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6D56_RS07135 1459526..1460719 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L6D56_RS07140 1460742..1463888 + 3147 WP_004147373.1 multidrug efflux RND transporter permease subunit AcrB -
L6D56_RS07145 1464374..1464748 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
L6D56_RS07150 1464775..1464993 + 219 WP_002892050.1 HHA domain-containing protein Toxin
L6D56_RS07155 1465152..1465718 + 567 WP_002892030.1 maltose O-acetyltransferase -
L6D56_RS07160 1465690..1465830 - 141 WP_004147370.1 hypothetical protein -
L6D56_RS07165 1465851..1466321 + 471 WP_002892026.1 YlaC family protein -
L6D56_RS07170 1466296..1467747 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
L6D56_RS07175 1467848..1468546 + 699 WP_040220001.1 GNAT family protein -
L6D56_RS07180 1468543..1468683 - 141 WP_040219999.1 type B 50S ribosomal protein L36 -
L6D56_RS07185 1468683..1468946 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T234207 WP_002892050.1 NZ_CP091650:1464775-1464993 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T234207 NZ_LR027873:c2593382-2593275 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT234207 WP_002892066.1 NZ_CP091650:1464374-1464748 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT234207 NZ_LR027873:2593198-2593258 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References