Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 371526..372060 Replicon plasmid unnamed
Accession NZ_CP091649
Organism Burkholderia aenigmatica strain CMCC(B)23010

Toxin (Protein)


Gene name parE Uniprot ID A0A2A4CB03
Locus tag L3V59_RS43865 Protein ID WP_059889265.1
Coordinates 371761..372060 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A2A4CA47
Locus tag L3V59_RS43860 Protein ID WP_059889264.1
Coordinates 371526..371771 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3V59_RS43835 (L3V59_43840) 366941..367165 + 225 WP_106357587.1 hypothetical protein -
L3V59_RS43840 (L3V59_43845) 367173..368345 - 1173 WP_059889257.1 tyrosine-type recombinase/integrase -
L3V59_RS43845 (L3V59_43850) 368506..369519 + 1014 WP_059889259.1 DNA-binding protein -
L3V59_RS43850 (L3V59_43855) 369516..369719 + 204 WP_059889261.1 hypothetical protein -
L3V59_RS43855 (L3V59_43860) 369700..370971 - 1272 WP_175900279.1 hypothetical protein -
L3V59_RS43860 (L3V59_43865) 371526..371771 + 246 WP_059889264.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
L3V59_RS43865 (L3V59_43870) 371761..372060 + 300 WP_059889265.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L3V59_RS43870 (L3V59_43875) 372207..372404 + 198 WP_059889267.1 hypothetical protein -
L3V59_RS44415 372747..372875 + 129 WP_258179664.1 hypothetical protein -
L3V59_RS43875 (L3V59_43880) 373411..374793 + 1383 WP_143331247.1 type I restriction-modification system subunit M -
L3V59_RS43880 (L3V59_43885) 374790..376859 + 2070 WP_179258893.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..448767 448767


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

Antitoxin ParD

(1-80)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11467.07 Da        Isoelectric Point: 9.8740

>T234205 WP_059889265.1 NZ_CP091649:371761-372060 [Burkholderia aenigmatica]
MPVKSRRVRLTPLAETDLEGIWRYTVERWSLEQAERYVGELVAAFERLAGSQGLGRPSRAGAGYRRYPVGSHVVFYRETP
DTLDVIRVLHQRMDVDRHL

Download         Length: 300 bp

>T234205 NZ_LR027873:c2300385-2300281 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8726.78 Da        Isoelectric Point: 6.4604

>AT234205 WP_059889264.1 NZ_CP091649:371526-371771 [Burkholderia aenigmatica]
MSRNTSISLGDHLSQFVDTQVASGRYGSASDVVRAGLRLLETQETELRVLQEALKAGEASGMPEAFDGPTFFARMRAKHA
G

Download         Length: 246 bp

>AT234205 NZ_LR027873:2300168-2300223 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4CB03

Antitoxin

Source ID Structure
AlphaFold DB A0A2A4CA47

References