Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 159423..160018 Replicon plasmid unnamed
Accession NZ_CP091649
Organism Burkholderia aenigmatica strain CMCC(B)23010

Toxin (Protein)


Gene name chpB Uniprot ID A0A2A4C4A8
Locus tag L3V59_RS42770 Protein ID WP_012218081.1
Coordinates 159668..160018 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A2A4C1X6
Locus tag L3V59_RS42765 Protein ID WP_012218082.1
Coordinates 159423..159674 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3V59_RS42735 (L3V59_42740) 155299..155574 + 276 WP_009693531.1 DUF4148 domain-containing protein -
L3V59_RS42740 (L3V59_42745) 155601..156104 + 504 WP_009693532.1 hypothetical protein -
L3V59_RS42745 (L3V59_42750) 156127..156852 - 726 WP_012211002.1 hypothetical protein -
L3V59_RS42750 (L3V59_42755) 157138..157929 - 792 WP_059888140.1 SOS response-associated peptidase family protein -
L3V59_RS42755 (L3V59_42760) 158060..158386 - 327 WP_012464905.1 H-NS histone family protein -
L3V59_RS42760 (L3V59_42765) 158551..159231 + 681 WP_012218083.1 site-specific integrase -
L3V59_RS42765 (L3V59_42770) 159423..159674 + 252 WP_012218082.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
L3V59_RS42770 (L3V59_42775) 159668..160018 + 351 WP_012218081.1 type II toxin-antitoxin system ChpB family toxin Toxin
L3V59_RS42775 (L3V59_42780) 160029..160541 + 513 WP_012218080.1 hypothetical protein -
L3V59_RS42780 (L3V59_42785) 160607..160789 + 183 WP_012218079.1 hypothetical protein -
L3V59_RS42785 (L3V59_42790) 160786..160947 - 162 WP_155295622.1 hypothetical protein -
L3V59_RS42790 (L3V59_42795) 161032..161364 + 333 WP_089454095.1 hypothetical protein -
L3V59_RS42795 (L3V59_42800) 161388..161957 + 570 WP_012218078.1 hypothetical protein -
L3V59_RS42800 (L3V59_42805) 162171..163115 + 945 WP_012218077.1 hypothetical protein -
L3V59_RS42805 (L3V59_42810) 163171..163425 + 255 WP_038442290.1 hypothetical protein -
L3V59_RS42810 (L3V59_42815) 163435..163878 + 444 WP_143331194.1 hypothetical protein -
L3V59_RS42815 (L3V59_42820) 163897..164256 + 360 WP_012218076.1 hypothetical protein -
L3V59_RS42820 (L3V59_42825) 164274..164483 + 210 WP_038442273.1 hypothetical protein -
L3V59_RS42825 (L3V59_42830) 164504..164893 + 390 WP_080512399.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..448767 448767


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-115)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12420.35 Da        Isoelectric Point: 8.9716

>T234204 WP_012218081.1 NZ_CP091649:159668-160018 [Burkholderia aenigmatica]
MVKRVKFDRGDIVRVSLNRTIGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGSGTETQGVALV
NMVRMLDLEARGARTIERAPAEVVEDALARLQSIIE

Download         Length: 351 bp

>T234204 NZ_LR027873:c2243026-2242817 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8997.39 Da        Isoelectric Point: 6.9770

>AT234204 WP_012218082.1 NZ_CP091649:159423-159674 [Burkholderia aenigmatica]
MELKIQKWGNSAAVRLPAVLLEQMHASVGGSLNADVRPDGVLLTPARRKYALDELVAQCDAKAPFPADMAAWGEVRPVGR
EGW

Download         Length: 252 bp

>AT234204 NZ_LR027873:c2243331-2243038 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4C4A8

Antitoxin

Source ID Structure
AlphaFold DB A0A2A4C1X6

References