Detailed information of TA system TA234202

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 2103014..2103579
• Replicon: chromosome
• Accession: NZ_CP091647
• Organism: Burkholderia aenigmatica strain CMCC(B)23010

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L3V59_RS27570
• Protein ID: WP_122948072.1
• Coordinates: 2103208..2103579 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A228INJ9
• Locus tag: L3V59_RS27565
• Protein ID: WP_069252544.1
• Coordinates: 2103014..2103211 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L3V59_RS27540 (L3V59_27540)	2098124..2098579	-	456	WP_237433748.1	RbsD/FucU family protein	-
L3V59_RS27545 (L3V59_27545)	2098659..2099078	-	420	WP_237433749.1	nuclear transport factor 2 family protein	-
L3V59_RS27550 (L3V59_27550)	2099365..2100918	-	1554	WP_237433750.1	galactarate dehydratase	-
L3V59_RS27555 (L3V59_27555)	2101148..2102062	+	915	WP_122948070.1	5-dehydro-4-deoxyglucarate dehydratase	-
L3V59_RS27560 (L3V59_27560)	2102177..2102731	-	555	WP_122948071.1	hypothetical protein	-
L3V59_RS27565 (L3V59_27565)	2103014..2103211	+	198	WP_069252544.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
L3V59_RS27570 (L3V59_27570)	2103208..2103579	+	372	WP_122948072.1	type II toxin-antitoxin system VapC family toxin	Toxin
L3V59_RS27575 (L3V59_27575)	2103726..2105303	-	1578	WP_237433751.1	aldehyde dehydrogenase (NADP(+))	-
L3V59_RS27580 (L3V59_27580)	2105551..2106930	+	1380	WP_237433752.1	MFS transporter	-
L3V59_RS27585 (L3V59_27585)	2107002..2107727	-	726	WP_043180875.1	site-2 protease family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-108)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-46)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13418.43 Da
• Isoelectric Point: 5.4683

>T234202 WP_122948072.1 NZ_CP091647:2103208-2103579 [Burkholderia aenigmatica]
MILVDTSVWIDHLRAGDVTLTTLLETERVLIHPFVIGELALGSLRDRQTVLDALRDLPVATSATDDEVQQMVDVVPLHGL
GIGYVDAHLLASVRLTDGSKLWTRDRRLLGAADRLGLAAHPAH

Nucleotide

• Length: 372 bp

>T234202 NZ_LR027873:c2004703-2004551 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7040.11 Da
• Isoelectric Point: 10.4525

>AT234202 WP_069252544.1 NZ_CP091647:2103014-2103211 [Burkholderia aenigmatica]
MRTTLSLDDALLAKAQQLTGVTEKSALVKEALRALIARESARRLARLGGTEPDLESIPRRPSEPA

Nucleotide

• Length: 198 bp

>AT234202 NZ_LR027873:c2005327-2004728 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A228INJ9